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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

A stereoselective synthesis of the C16-C32 fragment of ionomycin

Spino, Joseph Arthur Claude January 1988 (has links)
This dissertation concerns the stereoselective synthesis of optically pure compound 196, the C₁₆-C₃₂ fragment of the polyether antibiotic ionomycin (1). Fragment 196 was synthesized by preparing and joining the two subunits 172 (C₁₆-C₂₂) and 122 (C₁₆-C₃₂). Compound 172 was synthesized by repetitive asymmetric aldol condensations of optically pure crotonyl imide 69 with aldehydes 129 and 139. The use of 69 allowed for the enantioselective construction of the two propionate units of fragment 172 having the "anti" configuration. Compound 122 was synthesized using the highly stereospecific oxidative permanganate cyclization of the 1,5-diene 93 to give racemic tetrahydrofuran 94, having the correct relative stereochemistry at the four asymmetric centres. The diene 93 was in turn prepared via the β-keto ester dianion methodology which allows for the stereospecific introduction of the isoprenoid unit. Diol 103, derived from 94 was resolved as its mono (+)- ̲O̲-acetylmandelate and was transformed into optically active fragment 122. Finally, to complete the synthesis of optically active fragment C₁₆-C₃₂ of ionomycin, compounds 172 and 122 were coupled via a Wittig reaction to afford the cis olefin 194 and the second tetrahydrofuran ring of 196 was introduced stereoselectively via an internal oxymercuration reaction. / Science, Faculty of / Chemistry, Department of / Graduate
2

Total syntheses (-)-5-demethoxyfumagillol, (-)-fumagillol, (-)-RK-805,(-)-FR65814, and analogues

Li, Chengyong., 李成永. January 2008 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
3

An approach to lankacidin synthesis

Roe, Jane M. January 1990 (has links)
No description available.
4

Synthetic approaches to nonsteroidal anti-inflammatory agents via the ferrous ion initiated S←R←N1-reaction

Van Leeuwen, Milco January 1992 (has links)
No description available.
5

Synthetic approaches towards heterocyclic analogues of virantmycin / Michelle Anne Holman.

Holman, Michelle Anne January 1993 (has links)
Bibliography: leaves 168-176. / v, 178 leaves ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1994?
6

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Jackson, Michael D. 04 August 2000 (has links)
Graduation date: 2001
7

Synthetic studies on the macrolide antibiotic rutamycin B

Wang, Shan 23 January 1997 (has links)
Graduation date: 1997
8

Studies on naphthyridinomycin biosynthesis

He, Weixuan 20 May 1992 (has links)
Graduation date: 1993
9

Syntheses of labeled putative intermediates in acivicin biosynthesis

Jiang, Nan 29 January 1991 (has links)
Graduation date: 1991
10

The synthesis of macrolactones from [omega]-hydroxyacyl xanthates

Akella, Annapoorna 23 August 1991 (has links)
Graduation date: 1992

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