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<div>Stability of motor performance is important for voluntary movement control, but it should not be maximized to the exclusion of all else. To transition to a new task, the current task must be destabilized. When expecting to switch tasks, people are known to reduce their stability prior to initiating the change. Here, we determine if the observed stability modulation is influenced by the expectation of future movement, is a relic of the movements performed in the recent past, or is a consequence of both those processes. Furthermore, this work explores the relation between stability modulation observed in isometric finger force production tasks to cognitive flexibility and clinical measures of manual dexterity. Stability modulation can be viewed as a motor response to the recognition of altered environmental demands or internally generated desires to change body movements or postures. Therefore, it is hypothesized that cognitive flexibility – the efficacy of cognitive processing – will relate to stability modulation. Finally, it is hypothesized that the motor adjustments in response to changing task/environment demands will correlate with clinical tests of manual dexterity that involve placing pegs into holes.</div><div>Twenty-two young-adult participants (age 21.05 +/- 0.44 years) completed tasks in the three domains. The Grooved Pegboard and NIH 9-Hole tests of manual dexterity measured their manual function by time to complete the tests. Cognitive flexibility was measured by a task-switching task which required adjusting to a changing set of rules, and the reaction time and accuracy costs of task-switching were recorded. Lastly, participants’ stability of performance in an isometric finger-pressing task was assessed using the uncontrolled manifold analysis and root-mean-square error (RMSE) in the performance. Participants produced pressing forces with four fingers to match a single total force targets presented as feedback on a computer screen. In the ‘Steady’ task, target remained motionless. In the ‘Future Effects’ task, the target remained motionless for several seconds and then began moving. The ‘Past Effects’ task comprised of a dynamic initial portion followed by a stationary target. Lastly, the ‘Combined’ task had a constant force section flanked on either side by epochs of target movement. </div><div>The RMSE results confirmed the existence of stability modulation and established that this is driven by the expectation of future movement, and not by the history of previous movements. The Steady and Past Effects tasks exhibited higher stability than the Future Effects and Combined tasks. The stability estimates obtained from the uncontrolled manifold analysis showed similar trends. Cognitive flexibility (quantified as global accuracy cost) correlated with stability modulation indicating that individuals who show greater cognitive flexibility tend to demonstrate greater stability modulation. However, an association between stability modulation and clinical pegboard tests of manual function were not observed. This may possibly be due to the homogeneity of the test sample, or because the finger-force-production task and pegboard task measure disparate aspects of manual function. </div><div><br></div>

Os institutos clássicos do direito das obrigações, notadamente os conceitos de obrigação, adimplemento e inadimplemento precisam ser relidos à luz dos valores da Constituição Federal de 1988 e dos princípios e das cláusulas gerais trazidos pelo Código Civil de 2002, em especial a boa-fé objetiva. A noção tradicional de obrigação, consubstanciada na ideia de uma submissão do devedor ao credor, vem sendo paulatinamente abandonada em favor de um novo conceito de relação obrigacional, composto por direitos e deveres recíprocos que convergem para a consecução de um objetivo comum: o adimplemento. Assim examinado, o adimplemento consiste em um processo dinâmico dentro do qual o devedor deve executar uma série de atos e observar inúmeros deveres (principais, secundários e laterais) necessários ao adimplemento. Foi diante dessa premissa que a doutrina moderna começou a sustentar que a infringência de deveres de conduta e de deveres anexos ao longo da relação obrigacional pode configurar um inadimplemento antecipado do contrato, que se refere às hipóteses em que o inadimplemento resta configurado a despeito de ainda não se ter atingido o termo contratual. Esse estudo visará analisar o conceito e demonstrar a necessidade da consolidação do inadimplemento antecipado como um mecanismo de proteção do credor, examinando a sua possibilidade de aplicação no direito brasileiro, os seus requisitos, a sua natureza jurídica, os seus limites e os seus efeitos. / The classic institutes of contract law, notably the concepts of obligation, performance and breach of contract need to be reread pursuant to the values of the Federal Constitution of 1988 and the principles and general clauses brought by the Civil Code of 2002, in special the good faith. The traditional notion of obligation, based on the idea of the debtors submission to the creditor, has been gradually abandoned in favor of a new concept of obligatory relationship, composed of reciprocal rights and duties converging to achieve a common goal: performance. Thus, performance consists of a dynamic process in which the debtor must perform a series of acts and observe numerous duties (primary, secondary and lateral duties arising of good faith) necessary for performance. It was under this premise that modern legal scholars began to argue that any breach of duties along with the obligatory relationship can configure an anticipated breach of contract, which refers to cases in which the breach is affirmed before the contractual term. This essay aims to analyze the concept and demonstrate the need for consolidation of the anticipated breach as a creditor protection mechanism, examining its application possibility under Brazilian law, along with its requirements, legal status, limits and effects.

Os institutos clássicos do direito das obrigações, notadamente os conceitos de obrigação, adimplemento e inadimplemento precisam ser relidos à luz dos valores da Constituição Federal de 1988 e dos princípios e das cláusulas gerais trazidos pelo Código Civil de 2002, em especial a boa-fé objetiva. A noção tradicional de obrigação, consubstanciada na ideia de uma submissão do devedor ao credor, vem sendo paulatinamente abandonada em favor de um novo conceito de relação obrigacional, composto por direitos e deveres recíprocos que convergem para a consecução de um objetivo comum: o adimplemento. Assim examinado, o adimplemento consiste em um processo dinâmico dentro do qual o devedor deve executar uma série de atos e observar inúmeros deveres (principais, secundários e laterais) necessários ao adimplemento. Foi diante dessa premissa que a doutrina moderna começou a sustentar que a infringência de deveres de conduta e de deveres anexos ao longo da relação obrigacional pode configurar um inadimplemento antecipado do contrato, que se refere às hipóteses em que o inadimplemento resta configurado a despeito de ainda não se ter atingido o termo contratual. Esse estudo visará analisar o conceito e demonstrar a necessidade da consolidação do inadimplemento antecipado como um mecanismo de proteção do credor, examinando a sua possibilidade de aplicação no direito brasileiro, os seus requisitos, a sua natureza jurídica, os seus limites e os seus efeitos. / The classic institutes of contract law, notably the concepts of obligation, performance and breach of contract need to be reread pursuant to the values of the Federal Constitution of 1988 and the principles and general clauses brought by the Civil Code of 2002, in special the good faith. The traditional notion of obligation, based on the idea of the debtors submission to the creditor, has been gradually abandoned in favor of a new concept of obligatory relationship, composed of reciprocal rights and duties converging to achieve a common goal: performance. Thus, performance consists of a dynamic process in which the debtor must perform a series of acts and observe numerous duties (primary, secondary and lateral duties arising of good faith) necessary for performance. It was under this premise that modern legal scholars began to argue that any breach of duties along with the obligatory relationship can configure an anticipated breach of contract, which refers to cases in which the breach is affirmed before the contractual term. This essay aims to analyze the concept and demonstrate the need for consolidation of the anticipated breach as a creditor protection mechanism, examining its application possibility under Brazilian law, along with its requirements, legal status, limits and effects.

In a rapidly changing visual environment, the delay between perception and action might impair the probability of survival of a prey or the efficiency of a predator. In order to compensate for delays associated with sensory-motor processing, primates often make predictions about future events and initiate anticipatory movements. To prepare an anticipatory movement, an estimation of when and where to a target is likely to move is necessary. Such an internal representation is often termed 'expectation'. The aim of this thesis was to investigate the gradual changes of a subject's expectation at the behavioral and electrophysiological levels. Anticipatory smooth pursuit was used in order to study temporal and directional changes in expectation. We found that temporal uncertainty strongly modulated the latency and the velocity of anticipatory movements suggesting that monkeys could estimate the hazard rate of target motion onset in order to decide when to initiate an anticipatory movement. In addition, we have shown that monkeys could use prior directional information in order to voluntarily initiate anticipatory responses in the direction of expected target motion. This prior directional information significantly affected the latency and velocity of these movements. Finally, we have shown that the majority of recorded supplementary eye field (SEF) neurons encoded expected target motion direction. The presence of a directional cue induced an increase of activity in the preferred direction of the neuron. Moreover, a large sub-population of neurons encoded the direction of future anticipatory movement. These results suggest that the SEF could be involved in the cognitive control of anticipatory pursuit eye movements when prior temporal and directional information is provided.

Guilt appeals are used to try to influence consumer behavior, with literature defining three kinds – existential, anticipatory, and reactive guilt. Anticipatory and reactive guilt appeals have never been individually studied. The purpose of this study is hence to explain the relationship between anticipatory guilt and reactive guilt, respectively, inferences of manipulative intent, and consumers’ attitude toward a brand. To test this, an online questionnaire was used, followed by linear regression and moderation analyses. The results show a positive relationship between both anticipatory guilt and attitude and between reactive guilt and attitude. Inferences of manipulative intent do not moderate either relationship. Keywords Guilt appeal, anticipatory guilt, reactive guilt, inferences of manipulative intent, consumer brand attitudes

De acordo com Gray (1982) o sistema nervoso monitora o ambiente e o comportamento continuamente, sendo capaz de inibir o comportamento em curso quando se depara com novidades ou com discrepâncias entre expectativas geradas com base em memórias de regularidades passadas e a informação sensorial presente, de modo a explorar a fonte de novidade ou discrepância e, assim, obter informações que possibilitem gerar previsões melhores no futuro. O sistema septo-hipocampal compararia estímulos presentes com informações antecipadas (ou previstas). Tal sistema envolve um comparador, o subículo, que receberia informações do presente através de aferências neocorticais, via córtex entorrinal, e informações \"previstas\" geradas em um \"circuito gerador de previsões\". Gray (1982) propôs que esse circuito gerador de previsões inclui o subículo, os corpos mamilares, o tálamo anteroventral, o córtex cingulado e, novamente, o subículo. Destas estruturas, o tálamo anteroventral encontra-se em posição privilegiada, do ponto de vista hodológico e experimental, para investigar este postulado circuito gerador de previsões. O objetivo do presente trabalho foi investigar o efeito da lesão seletiva no tálamo anteroventral, pela aplicação tópica de ácido N-metil-D-aspártico (NMDA), sobre a habilidade de ratos extrapolarem a partir de padrões seriais de estímulos. Tampão fosfato foi aplicado em sujeitos controle. Ratos da linhagem Wistar, machos, foram treinados a correr em uma pista reta para receberem reforço ao seu final. Em cada sessão (uma sessão por dia), os animais correram 4 tentativas sucessivas, recebendo quantidades diferentes de sementes de girassol em cada tentativa. No padrão monotônico decrescente os sujeitos receberam 14, 7, 3 e 1 sementes de girassol, enquanto os sujeitos expostos ao padrão não-monotônico receberam 14, 3, 7 e 1 sementes de girassol. Os animais foram treinados ao longo de 31 sessões. No 32° dia do experimento, uma quinta tentativa, nunca antes experienciada pelos animais, foi adicionada à sessão. Como esperado, os tempos de corrida na quinta tentativa dos animais controle expostos ao padrão monotônico decrescente foram substancialmente maiores se comparados aos animais controle expostos ao padrão não-monotônico, indicando a ocorrência de extrapolação. Em contraste, os sujeitos lesados expostos ao padrão monotônico não exibiram esse aumento de latência na quinta corrida, indicando que esses animais não extrapolaram. Em conclusão, os resultados indicam que extrapolação a partir de padrões seriais de estímulos é prejudicada pela lesão seletiva do tálamo anteroventral / According to Gray (1982) the brain continuously monitors environment and behavior, being capable of inhibiting ongoing behaviors when facing novelty or detecting discrepancies involving predictions generated from memories of past regularities and the actual sensorial information, in order to explore the source of novelty and/or discrepancy, and thus to gather information for generating better predictions in the future. The septo-hippocampal system compares anticipated and present information. The comparator would be the subiculum. This brain structure would receive present information from neocortical afferents, via the entorhinal cortex, and expected information from a \"generator of predictions system\" including the subiculum, mammillary bodies, anteroventral thalamus, cingulate cortex and, again, the subiculum. The anteroventral thalamus is in a privileged position, both hodologically and experimentally, to allow investigation of this postulated generator of predictions system. This study investigated the effect of selective damage to the anteroventral thalamus, by topical application of N-Methyl-D-Aspartic acid (NMDA), on the ability of rats to extrapolate relying on serial stimulus patterns. Control subjects were injected with phosphate buffer. Male Wistar rats were trained to run through a straight alleyway to get rewarded. In each session (one session per day) the animal run four successive trials, one immediately after the other, receiving different amounts of sunflower seeds in each trial. While subjects exposed to the monotonic decremental schedule received 14, 7, 3, 1 sunflower seeds along trials, subjects exposed to the non-monotonic schedule received 14, 3, 7, 1 sunflower seeds. Subjects were trained along 31 sessions. Then, on the 32nd testing session, a fifth trial never experienced before by all subjects was included immediately after the fourth trial. As expected, running times on the fifth trial for Control subjects exposed to the monotonic schedule were significantly longer as compared to the corresponding scores of Control subjects exposed to the non-monotonic schedule, thus indicating the occurrence of extrapolation. In contrast, lesioned subjects exposed to the monotonic schedule did not exhibit this increase in running times on the fifth trial thus indicating that these subjects did not extrapolate. In conclusion, results indicate that extrapolation relying on serial stimulus patterns is disrupted following selective damage to the anteroventral thalamus