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PATIENT ACTIVATION AND MEDICATION ADHERENCE AMONG MEDICARE BENEFICIARIES WITH TYPE 2 DIABETESDandan Zheng (5930957) 17 January 2019 (has links)
The objectives of this study were to assess
patient activation levels, to assess association between sociodemographic
characteristics and patient activation, to assess association between health
status characteristics and patient activation, and to assess association
between patient activation and medication adherence among Medicare
beneficiaries with type 2 diabetes. A
retrospective cohort study was conducted using data from the 2009 through 2013 Medicare
Current Beneficiary Survey (MCBS).
Patient activation was measured with the Patient Activation Supplement
in the MCBS and was categorized as low, moderate, and high levels based on
activation scores. Medication adherence was assessed with
proportion of days covered (PDC) using Medicare Part D administrative records
from the MCBS within a period of six months after measurement of patient
activation. The
sample included Medicare beneficiaries who completed the MCBS Patient Activation
questionnaire, who were diagnosed with type 2 diabetes, and who were 18 or
older. Beneficiaries were excluded if
they responded “Not ascertained,” “Not Applicable,” “Don’t know” or “Refused”
to more than 50 percent of the Patient Activation questions, did not have
continuous Medicare Part A and Part D coverage throughout the assessment
period, had less than two Medicare Part D claims for an antidiabetic medication
throughout the assessment period, used insulin during the assessment period,
resided in long-term care facilities, or had Alzheimer’s disease, dementia,
mental retardation or mental disorder. All analyses were conducted in SAS 9.4 for Unix environment. An <i>a
priori</i> alpha level of 0.05 was used to determine significance. Bivariate and multivariable
weighted ordinal logistic regression were applied for assessing associations. A
total of 571 individuals met sample selection criteria. The mean age was 72.4
years. Of the 571 persons in the sample,
27.5 percent were at low activation level, 38.7 percent were at moderate
activation level, and 33.7 percent were at high activation level. Approximately three-fourths of the sample persons were adherent to antidiabetic medications. Low activation was more
likely to be found in males, less educated patients, and patients without
arrhythmia. Ex-smokers as compared to
non-smokers and overweight patients as compared to those with healthy weight
were less likely to report low activation.
In multivariable logistic analysis adjusting for race, gender,
osteoporosis, Charlson Comorbidity Index score, and number of prescribed
medications, patient activation level was not significantly associated with
medication adherence. Non-Whites
and patients with a Charlson Comorbidity Index score of 1 as
compared to those with a score of 0 were more likely to be non-adherent. A lower number of prescribed medications was
associated with higher odds of non-adherence.
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Adherence to oral antidiabetic medications in the pediatric population with type 2 diabetesAdeyemi, Ayoade Olayemi 12 July 2011 (has links)
The present study involved the analyses of the Texas Medicaid prescription claims data. The population studied was made up of subjects between 10 and 18 years who had at least 2 prescriptions of the same oral antidiabetic (OAD) medication from January 1, 2006 through December 31, 2009. Twelve months’ data for each subject were analyzed. The main aim of the study was to describe OAD medication use patterns in the study population, assess trends in Medication Possession Ratio (MPR) and persistence in the study population and determine the relationship between age and MPR and between age and persistence while controlling for covariates. Results of the descriptive statistics, multiple and logistic regression analyses are reported.
The average age (± SD) of the 3,109 eligible subjects was 14 (± 2) years; minority populations made up the majority (87%) of the population; 67% of the population were females; and 91% were on the OAD metformin. The overall mean MPR (± SD) for the population was 45% (± 27). A significant negative relationship between MPR and age was reported while controlling for covariates (p<0.0001). Among the covariates, white race and male were significantly associated with a higher MPR, holding other variables constant. When adherence was dichotomized (MPR < 80% and MPR >= 80%), logistic regression analysis also found that age was significantly and negatively related to MPR (p < 0.0001). In addition, the white race and male were again significantly related to a higher level of adherence, holding other variables constant.
The overall mean days to non-persistence (± SD) was 108 days (± 86). Persistence was significantly and negatively associated with age, holding other variables constant (p < 0.0001). Among the covariates, white race was significantly related to longer persistence.
In conclusion, adherence and persistence are generally low in the study population. Age, gender and race were significantly associated with adherence. Being younger, male, and white were significantly associated with a higher level of adherence, while being younger and white were significantly associated with longer persistence. Healthcare providers therefore need to intensify efforts to improve adherence in pediatric patients especially those at the brink of adulthood. / text
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Examining adherence with medications used in treating diabetic peripheral neuropathic painOladapo, Abiola Oluwagbenga 03 January 2011 (has links)
The present study is a retrospective cohort analysis which sought to examine adherence to medications used in managing painful diabetic peripheral neuropathy (PDPN) and to determine their association with oral antidiabetic (OAD) medication adherence using the Texas Medicaid prescription claims database. The study objectives were to: 1) provide a description of PDPN and OAD medication use among the study subjects; 2) determine if PDPN medication adherence differs among individual PDPN agents (i.e., tricyclic antidepressants, gabapentin, pregabalin and duloxetine); 3) determine if pre-index OAD and post-index OAD medication adherence differs among mono, dual, and triple OAD therapies; and 4) determine if PDPN medication adherence is related to post-index OAD medication adherence while controlling for covariates. Study participants were adult (≥18 years) Medicaid beneficiaries prescribed OAD and PDPN medications. The index date was the first PDPN prescription. Data were extracted from June 1, 2003 to October 31, 2009 and prescription claims were analyzed over an 18-month study period (i.e., 6 months pre-index and 12 months post index period). Medication possession ratio (MPR) was used as a proxy measure of medication adherence. An MPR less than 80 percent was regarded as being non-adherent to prescribed medication, while an MPR greater than or equal to 80 percent was regarded as being adherent to prescribed medication. Objective 1 was addressed using descriptive statistics (i.e., mean, standard deviation, frequency). Univariate analysis (ANOVA) was employed to address Objectives 2 and 3. Multivariate analyses (i.e., multiple linear regression and logistic regression) were conducted to address Objective 4. For the logistic regression MPR was dichotomized at the cut-off value of 80 percent.
A total of 4,277 patients met the study’s inclusion criteria. The overall mean MPR (±SD) for PDPN medications was 75.4 percent (±23.9). Mean MPR (±SD) was highest for duloxetine (85.6% ±18.2) and was lowest for pregabalin (69.4% ±24.9). Mean MPR differed significantly among individual PDPN medications (p<0.0001). The overall mean MPR (±SD) for OAD medications in the pre and post-index period was 73.0 percent (±24.3) and 64.5 percent (±25.6) respectively. In both pre and post-index periods, mean MPR differed significantly among mono, dual, and triple OAD therapies (p<0.0001). In the pre-index period, mean MPR (±SD) was highest for monotherapy users (75.4% ±24.7) and was lowest for triple therapy users (63.9% ±22.9). Similarly, mean MPR (±SD) was highest for monotherapy users (69.0% ±26.1) and was lowest for triple therapy users (52.9% ±21.8) in the post-index period. After controlling for the covariates, PDPN adherence (i.e., MPR) was statistically significant (p<0.0001) and positively related to post-index OAD adherence (i.e., MPR). PDPN patients who were non-adherent (i.e., MPR<80%) to their PDPN medications (or neuropathic pain medications), compared to those who were adherent (MPR≥80%), were significantly less likely to be adherent to their OAD medications [Odds Ratio (OR) = 0.626, 95% CI=0.545-0.719]. In addition, post-index OAD adherence (i.e., MPR) did not differ significantly (p>0.05) when pregabalin, duloxetine and gabapentin users were individually compared to tricyclic antidepressants users.
In conclusion, PDPN patients who were adherent (i.e., MPR≥80%) to their PDPN medications, compared to those who were not adherent (i.e., MPR<80%), were more adherent to their OAD medications. Also, adherence to OAD medications was independent of the type of PDPN medication used. PDPN patients need to be educated regularly that neuropathic pain medications only relieve the pain associated with the neuropathy but achieving adequate glycemic control remains the only established approach for slowing down the progression of the neuropathy and other complications associated with the diabetes. / text
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