Global ETD Search

221	Preclinical studies of roscovitine / Vita, Marina, January 2005 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 5 uppsatser.
222	Signaling pathways modulated by gold-1A in its anti-tumour effects against hepatocellular carcinoma Li, Hoi-yee., 李凱怡. January 2006 (has links) published_or_final_version / abstract / Chemistry / Master / Master of Philosophy Antineoplastic agents. Apoptosis - Molecular aspects. Liver - Cancer - Chemotherapy.
223	Luminescent cyclometalated platinum (II) complexes in DNA binding studies and their cytotoxicities against carcinoma cell lines Ma, Dik-lung, Edmond., 馬迪龍. January 2003 (has links) published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy Antineoplastic agents. Platinum compounds. Cancer cells - Genetics. Apoptosis.
224	Functionalized platinum (II) and gold (I) acetylide complexes: structural and spectroscopic properties andanticancer activities Shum, Yuen-ting., 岑婉婷. January 2007 (has links) published_or_final_version / abstract / Chemistry / Doctoral / Doctor of Philosophy Acetylene compounds - Spectra Platinum compounds. Gold compounds. Antineoplastic agents.
225	Study of mammalian target of rapamycin (mTOR) signaling and the effects of its specific inhibitors in hepatocellular carcinoma Hui, Chun-fai, Ivan., 許振輝. January 2007 (has links) published_or_final_version / abstract / Pathology / Master / Master of Philosophy Rapamycin. Antineoplastic agents. Cancer cells - Proliferation. Liver - Cancer - Chemotherapy.
226	Potential biomedical application of metallic nanoparticles To, Yuk-fai., 杜鈺輝. January 2007 (has links) published_or_final_version / abstract / Surgery / Doctoral / Doctor of Philosophy Nanoparticles. Nanotechnology. Antineoplastic agents. Esophagus - Cancer - Chemotherapy. Nasopharynx - Cancer - Chemotherapy.
227	In vitro and in vivo studies of cytotoxic and anti-angiogenic cyclometalated gold(III) and gold(III) porphyrin complexes Li, Ka-lei, Carrie., 李嘉莉. January 2008 (has links) published_or_final_version / abstract / Chemistry / Doctoral / Doctor of Philosophy Gold compounds. Porphyrins. Complex compounds. Apoptosis. Neovascularization inhibitors. Antineoplastic agents.
228	Luminescent cyclometalated platinum (II) complexes with isocyanide ligands as nucleic acid probes, topoisomerase poisons and anti-cancers agents Liu, Jia, 刘佳 January 2011 (has links) published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy Antineoplastic agents Platinum compounds Nucleic acid probes DNA topoisomerases Ligands
229	Design, synthesis, conformation and biological activities of cyclic alpha-melanotropin and related compounds. Ahmed, Al-Obeidi Fahad. January 1988 (has links) This research initiated an investigation of the structural relationships between melanocyte stimulating hormone (α-MSH) and its melanin dispersion on lizard (Anolis carolinensis) and frog (Rana pipiens) skins bioassays as representing models for mammalian and amphibian melanocytes, respectively. From previous extensive structure-activity relationships of α -MSH together with the theoretical modeling we were able to design a group of linear and cyclic peptides related to "4-10" fragment analogues of α -MSH. The solid phase synthesis of α -MSH and its related analogues using the p-methyl-benzhydrylamine resin was accomplished. The C-terminal carboxamide and N-terminal acetylamide were maintained in all peptides synthesized. The cyclic peptides were prepared in solution phase using the linear peptides generated by solid phase. All the cyclization were done by using the hydrochloride salts of the peptide and DMF as solvent with diphenylphosphoryl azide (DPPA) as a coupling reagent in the presence of K₂HPO₄ as a base. The yields of the cyclic peptides were in the range of 30-40 percent. In all the synthesized peptides the replacement of D-Phe⁷ with L-Phe⁷ causes reduction in the potency of the peptide on lizard or frog skins bioassays. Also, the reduction or increase in ring size in the cyclic peptide from a 23 membered ring diminishes the biological effect of the peptide under testing. Doxorubicin -- Side effects. Drug resistance. Antineoplastic agents -- Side effects.
230	An investigation into the influence of bridging diamine linkers on the substitution reactions of dinuclear platinum II complexes. January 2005 (has links) Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2005. Platinum compounds. Transition metal compounds. Antineoplastic agents. Theses--Chemistry.

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