by Walubo Andrew. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1991. / Bibliography: leaves 148-174. / ABSTRACT --- p.i / declaration --- p.iv / acknowledgements --- p.v / Chapter chapter 1 --- general introduction --- p.1 / Chapter chapter 2 --- literature review --- p.5 / Chapter section 1 --- isoniazid --- p.5 / Chapter section 2 --- rifampicin --- p.19 / Chapter section 3 --- pyrazinamide --- p.27 / Chapter section 4 --- an overview of the use of antituberculous drugs in uganda and hong kong --- p.30 / Chapter section 5 --- review of analytical methods --- p.40 / Chapter section 6 --- conclusions from the reviews --- p.44 / Chapter chapter 3 --- some principles of pharmacokinetics --- p.47 / Chapter section 1 --- introduction --- p.47 / Chapter section 2 --- application of pharmacokinetics --- p.55 / Chapter chapter 4. --- aims of the present project --- p.66 / Chapter chapter 5 --- chromatographic methods --- p.68 / Chapter section 1 --- a simultaneous assay for isoniazid and hydrazine metabolite in plasma and cerebrospinal fluid in the rabbit --- p.68 / Chapter section 2 --- a simultaneous assay for rifampicin and pyrazinamide in human plasma --- p.89 / Chapter chapter 6 --- the pharmacokinetics of isoniazid and hydrazine metabolite in the plasma and cerebrospinal fluid of rabbits --- p.91 / Chapter chapter 7 --- the disposition of anti-tuberculous drugs in the plasma of elderly patients --- p.108 / Chapter SECTION 1 --- METHODS --- p.109 / Chapter SECTION 2 --- CLINICAL ASSESSMENT --- p.112 / Chapter SECTION 3 --- GENERAL FINDINGS. --- p.117 / Chapter 1)- --- THE DISPOSITION OF ISONIAZID AND HYDRAZINE METABOLITE IN THE PLASMA OF ELDERLY PATIENTS --- p.117 / Chapter 2) - --- "THE DISPOSITION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN THE PLASMA OF ELDERLY PATIENTS" --- p.129 / Chapter SECTION 4 --- CASE REPORT --- p.139 / Chapter CHAPTER 8 --- p.145 / Chapter SECTION 1 --- GENERAL CONCLUSIONS --- p.145 / Chapter SECTION 2 --- FUTURE STUDIES --- p.147 / REFERENCES --- p.148 / APPENDICES: --- p.AO / Chapter APPENDIX A --- (WORK SHEETS) --- p.AO / Chapter APPENDIX B --- (SCIENTIFIC COMMUNICATIONS) --- p.BO