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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 7 of 7 (0.079 seconds)Spelling suggestions: "subject:"antitumour antibiotic"" "subject:"antitumours antibiotic""
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Synthetic studies towards a novel DNA targeted cross-linking agent based on DC-81 and CC-1065Croker, Stephen John January 1997 (has links)
No description available.
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Structural modification of DNAGriffiths, Jonathan January 1991 (has links)
No description available.
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Design, synthesis and evaluation of linkers for the solid phase synthesis of pyrrolo [2,1-c][1,4] benzodiazepinesSpencer-Evans, Victoria Louise January 2003 (has links)
No description available.
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Synthesis and reactions of cyclopropamitosenes and related pyrrolo[1,2-a]indolesO'Sullivan, Noeleen January 1992 (has links)
The use of Mitomycin C in the treatment of a wide range of neoplastic conditions is discussed. The mechanism of action of mitomycin anticancer antibiotics under reductive activation conditions using either enzymes, sodium dithionite, catalytic hydrogenation or chromium (Il) perchlorate is examined, as is the alkylation of DNA. An intramolecular [3+2] cycloaddition strategy has been employed to synthesise the pyrrolo[I,2-aJ]indole nucleus for a wide range of cyclopropamitosenes, whereas the key step in the synthesis of pyrrolo[I ,2-a]indoles without the cyclopropane ring was a modified Wittig reaction. From the onset of the work it was important to investigate the role of the 7 -methoxy group. Hence a variety of cyclopropamitosenes or related pyrrolo[I,2-a]indoles were subjected to C-7 exchange reactions with either (i) other alkoxides or (ii) cyclic / acyclic amines. In this way, structural modification at C-7 can be related to the biological results. Biological and electrochemical data were recorded for the cyclopropamitosenes and related pyrrolo[I,2-a]indoles and correlated with their structures.
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A new approach to the synthesis of DNA-interactive pyrrolo-[1,4]-benzodiazepin-5-onesMurray, Clare Louise January 1996 (has links)
No description available.
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The synthesis of novel DNA-interactive pyrrolo-(2,1-c)[1,4]-benzodiazepin-5-onesThompson, Stephen January 2000 (has links)
No description available.
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The design, synthesis and evaluation of a novel DNA cross-linking agent based on the pyrrolobenzodiazepinesLobo, Sylvia Grace Marianne Jean January 1996 (has links)
No description available.
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