Spelling suggestions: "subject:"anxiety; 1emale rate; phencyclidine"" "subject:"anxiety; 1emale rate; phencyclidin""
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Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open fieldMcLean, Samantha L., Woolley, M.L., Neill, Joanna C. 05 March 2009 (has links)
Yes / Female hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a seven-day washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the sub-chronic PCP treated rats. Rats were then tested on the elevated plus maze and in an open field for 10 minutes. Sub-chronic PCP did not significantly affect behaviour on the elevated plus maze or in the open field. In conclusion, sub-chronic PCP does not induce anxiety-like behaviour.
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