Catheter ablation is a unique method for cardiac arrhythmias treatment based on creating spot lesions of radiofrequency energy using intracardiac ablation catheter. Transmurality of these lesions should be achieved for long-term therapeutic treatment effect. The degree of myocardial damage depth is reflected in the parameters of sensed intracardiac ECG. From research studies is evident that the change in morphology and deflection of ablation signal play a key role in the assessment of transmurality. This thesis consists of theoretical introduction to electrophysiology, proposal and realization of methods for objective assessment of transmurality by processing signals in time, frequency and time – frequency domain. The end of this diploma thesis includes the statistical analysis of these clinical dat and comparison of methods.

The ROC (Receiver Operating Characteristic) curve is a projection of two different cumulative distribution functions F0 and F1. On axis are values 1-F0(c) and 1-F1(c). The c-parameter is a real number. This curve is useful to check quality of discriminant rule which classify an object to one of two classes. The criterion is a size of an area under the curve. To solve real problems we use point and interval estimation of ROC curves and statistical hypothesis tests about ROC curves.