published_or_final_version / Psychology / Doctoral / Doctor of Philosophy

Thesis--Ph. D., University of Hong Kong. / Includes reprints of 4 papers by the author and others in the appendices.

Thesis (Ph. D.)--Victoria University (Melbourne, Vic.), 2007. / Includes bibliographical references.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 74-86). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 74-86). Also available on the Internet.

Thesis (Ph. D.)--UCLA, 2009. / Vita. Description based on print version record. Including bibliographical references (leaves 117-126).

The overarching purpose of this work is to expand the utility of pupillometry as a non-invasive index of pupil-linked neuromodulatory systems, which are correlated with behavior states and are integral in carrying out complex behaviors, such as decision-making. The work characterizes tonic pupil dynamics and their relation to brain state and behavior (B. J. Schriver, S. Bagdasarov, & Q. Wang, 2018), characterizes the mechanisms and functional consequences behind phasic arousal linked pupil dynamics, and examines the causal role of the locus coeruleus in mediating the relationship between pupil dynamics, arousal, and ultimately behavior. For characterization of tonic pupil dynamics in the awake, behaving animal, rats were shown to be able to discriminate between directions of whisker deflections in a Go/No-Go behavioral paradigm with behavioral outcomes being associated with unique pupil dynamics. Furthermore, pupil baseline was inversely correlated with pupil dilation. Our work found that the behavior of rats performing the tactile discrimination task was highly dependent on pupil-indexed level of arousal. Pupil baseline exhibited an inverted U-shaped relationship with perceptual sensitivity and a U-shaped relationship with decision criterion. Shorter reaction times were also associated with higher perceptual sensitivity, more liberal decision criterion, and larger pupil baseline. We also found that behavioral outcomes influenced upcoming pupil dynamics and behavior. Altogether, we observed that there existed tight correlations between pupil dynamics, perceptual performance, and reaction time, all of which were influenced by fluctuating behavior state. For characterization of the mechanisms and functional consequences behind phasic pupil dynamics in the awake, behaving animal, task-evoked pupil responses were first shown to differ according to their underlying cognitive processes. Task-evoked pupil responses are composed of a superposition of elementary components and this work showed that individual responses could be decomposed into the sum of their weighted, time-locked generalizable pupil-linked phasic arousal inputs. These phasic arousal inputs were separate from inputs controlling baseline related arousal fluctuations. We found distinct contributions to phasic arousal were made by stimulus encoding and decision-formation. Looking at these independently suggested differences in the underlying phasic arousal related mechanisms in driving the animals towards outcomes contingent on stimulus identity. Furthermore, drift-diffusion modeling revealed that interplay between phasic arousal evoked by both stimulus encoding and decision formation had important functional consequences on forming behavioral choice in perceptual decision-making. We also observed a central role of the locus coeruleus-norepinephrine (LC-NE) system in modulating pupil-linked behavioral state. Both electrical and optogenetic activation of the LC-NE system mediated pupil dilation. Furthermore, trial-by-trial LC-NE system activation via channelrhodopsin-2 (ChR2) increased perceptual sensitivity in a difficulty dependent manner, with more pronounced improvement occurring when distracting stimuli were more similar to the target stimulus.

No description available.

This study investigated the differences between right and left hemisphere brain damaged (BD) patients and controls in response to verbal and spatial-affective stimuli. The three null hypotheses explored in this study were: (a) Right hemisphere BD patients would not display significantly different arousal levels from controls in response to verbal and spatial-affective stimuli, (b) left hemisphere BD patients would not display significantly different arousal levels from controls in response to verbal and spatial-affective stimuli, and (c) left hemisphere BD patients would not display significantly different arousal levels from right hemisphere BD patients in response to verbal and spatial-affective stimuli. A One-Way Analysis of Variance was used to determine if differences in arousal existed between right and left hemisphere BD patients and controls. Planned comparisons (t-tests) were used in analyzing the hypotheses.A total of 48 subjects was used in this study. Experimental subjects were composed of 16 left and 16 right hemisphere BD patients from Community Hospital, Indianapolis, Indiana. Sixteen control subjects were obtained from the community of Muncie, Indiana. All subjects were volunteers. No significant differences were found between right and left hemisphere BD patients and controls with respect to age, education, and post injury.The instruments used in this study were a J & J electrodermal unit, the Affective Behavior Test, and the Comprehension subtest of the Wechsler Adult Intelligence Scale-Revised. All tests were individually administered while GSR recordings were obtained. Administration, scoring, computer analyses, and interpretation was completed between May 1982 and February 1984.All three null hypotheses were rejected. Right and left hemisphere BD patients' arousal levels in response to affective stimuli were significantly different from those of controls (p <.001). These results suggested that arousal levels in right and left hemisphere BD patients were lower than non-brain damaged individuals. Additionally, right hemisphere BD patients were found to have significantly lower arousal levels than left hemisphere BD patients (p<.01). In light of these findings, it was recommended that future research explore the value of increasing arousal levels for cerebrovascular accident patients in the rehabilitative process.

Thesis (M.D.)--University of Adelaide, 1986. / Includes bibliographical references (leaves 317-350).