Background: The demand for organ donation is increasing but there is always a lack of organ donor supply. To receive an organ donation, specific criteria must be met. Matching criteria between the donor and the recipient is critically important. The likelihood of having a capable organ increases when the donors and recipients have the same ethnicity. However, the number of organ donors differ significantly based on ethnicity. Purpose: The purpose of this literature review was to explore the impact of cultural background and education among the Asian and non-Hispanic White population on organ donation and how it impacts individuals' decisions on becoming organ donators. Methods: To explore the impact of cultural background and education on the Asian and non-Hispanic White population regarding organ donation, a literature review was conducted. The databases including, CINAHL Plus with Full Text and MEDLINE were utilized. Google Scholar was used for additional articles related to the topic. The time frame of the articles was from January 2012 to January 2022, a ten-year frame. Results: Overall, the Asian population had a lower deceased organ donation rate and registration rate in comparison to the non-Hispanic White population. The factors that contributed to low organ donation and registration include traditional religion, lack of knowledge, miscommunication, mistrust in the healthcare system, and consideration of family members' attitudes. Conclusion: Organ donation and registration rates remain low in the Asian population in comparison to the non-Hispanic White population due to several barriers related to their cultural background. Thus, it is critical to educate the patients and their family members regarding organ donation to increase the organ donation and registration rate.