Thesis (M.S.)--University of Michigan, 1981.

Thesis (M.S.)--University of Michigan, 1981.

Thesis (M.S.)--University of Michigan, 1982.

Thesis (M.S.)--University of Michigan, 1982.

A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. / Dysphagia with aspiration (DA) is the most common presenting symptom of patients at Phoenix Children’s Hospital’s Aerodigestive Clinic (ADC). Dysphagia with aspiration is associated with respiratory and gastrointestinal symptoms, chronic oral thickener use to prevent aspiration, secondary constipation, and occasionally, enteral tube dependency. MBS is considered the gold standard in instrumental assessment of dysphagia; it is used to evaluate severity and guide thickener treatment of DA patients, monitor progress with serial studies, and for re‐evaluation after intervention when appropriate. Previous evaluation of patients with deep interarytenoid notch given laryngoplasty injection included patients with improvement in symptoms despite post‐intervention MBS scores worsening, and vice versa, challenging the use of MBS as a longitudinal tool in clinical evaluation of patients with dysphagia and aspiration. Is MBS severity score reflective of clinical symptoms in pediatric patients with dysphagia and aspiration? A clinical questionnaire of DA symptoms was developed with input from the ADC physicians. The questionnaire was administered over 3 months to patients aged 1‐3 years who had an MBS evaluation within 6 months of their initial ADC visit, standard of care for patients with DA. 17 symptoms (12 GI and 5 pulmonary) were given a numerical score 0‐4 based on parent recall of frequency. MBS was scored 1‐10 on the thickness of liquid recommended for aspiration prevention. Individual symptoms and symptom sets (total questionnaire score, GI score, pulmonary score) were compared to MBS score using linear regression model. 30 patients were surveyed with median MBS score of 6 and range from 0 to 8. 18 patients had an MBS score above 6. Median questionnaire score was 18, with a range from 4 to 53. All analysis showed no significant correlation between individual symptoms or symptom sets and MBS score; the highest R2 value for any individual symptoms was 0.05. Among ADC patients with DA, MBS severity score did not correlate with severity or specificity of symptoms, questioning the use of MBS as a tool for diagnosing severity of persistent DA or as a repetitive tool in assessing response to laryngeal cleft surgical interventions and thickener wean therapy. These findings challenge the use of repetitive MBS in the ADC patient population. Our ultimate goal is to develop a combined clinical and radiologic tool that would minimize radiation exposure and unnecessary thickener treatment while promoting best clinical outcomes.

This study evaluates the anomie theory of juvenile delinquency with empirical data drawn from a sample population of junior and senior high school students. This research originates from the findings published by Bernard Rosenberg and Harry Silverstein in The Varieties of Delinquent Experience, a portion of which this study partially replicates.

No description available.

No description available.

Cette étude propose une analyse phonologique de l'aspiration en grec ancien, fondée sur un examen approfondi des sources à la lumière des données phonétiques et typologiques des langues contemporaines. Les propriétés de transparence et de mobilité de l'aspiration sont expliquées par une représentation autosegmentale : h est incapable d'occuper une position temporelle à lui seul. Cette propriété rend compte du comportement de l'aspiration dans les composés, au sein d'une analyse plus large de la structure du mot prosodique. L'aspiration, ensuite, n'est pas seulement plus robuste, et donc mieux conservée, en position initiale : une aspiration interne est aussi attirée dans cette position. Cette propriété explique la distribution de l'aspiration, et les cas d'assimilation relevés dans le corpus épigraphique. L'aspiration systématique de u- et de r- initial est analysée comme un reliquat du système des sonantes en grec archaïque, dont nous proposons une reconstruction révisée. Cette analyse montre que les sonantes aspirées sont préférées aux sonantes à voisement modal à l'initiale de mot prosodique. Cette contrainte n'est plus active en grec classique ; en particulier, nous montrons que l'aspiration de r ne dépend plus de la position initiale, mais de sa longueur. Nous analysons le r initial en grec classique comme une vibrante longue, traitée par la phonologie comme les groupes pt- initiaux. Enfin, nous proposons une analyse de la dissimilation régressive d'aspiration connue sous le nom de « loi de Grassmann », dont les effets sont articulés avec les autres propriétés de l'aspiration sur les plans synchronique et diachronique. / This study proposes a phonological analysis of aspiration in Ancient Greek, based on an in-depth examination of the sources and on the comparison with phonetic and typological patterns in contemporary languages. The transparency and mobility of aspiration are accounted for by an autosegmental representation: h cannot be associated with its own temporal slot. This property explains its behaviour within compounds, and is integrated into a broader analysis of the prosodic word structure. Aspiration is not only more robust and thus better preserved in initial position: internal aspiration is also attracted to this position. These properties account for the distribution of aspiration and the assimilations that appear in the epigraphical corpus. The systematic aspiration of initial u and r is analysed as a relic of the sonorant system in Archaic Greek, for which we pro​pose a revised reconstruction. The resulting analysis shows that aspirated sonorants are preferred over sonorants with modal voicing at the beginning of a prosodic word. This constraint is no longer active in Classical Greek: we show that the aspiration of r is not linked to the initial position any more, but to its length. We analyse the initial r of Classical Greek as a long trill, treated by the phonology like the initial pt- clusters. Finally, we propose an analysis of the regressive dissimilation of aspiration known as ``Grassmann's Law", whose effects are articulated with the other properties of aspiration in a diachronic and synchronic account.

Made available in DSpace on 2014-06-11T19:29:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-13Bitstream added on 2014-06-13T18:39:03Z : No. of bitstreams: 1 padilha_lc_me_jabo.pdf: 434491 bytes, checksum: 2a50d470304fd06e3ea6f8741e8c34d9 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / O sucesso da produção in vitro de embriões requer a utilização de uma técnica de recuperação eficiente de oócitos, e os melhores resultados têm sido obtidos pela aspiração laparoscópica. O objetivo deste trabalho foi avaliar os efeitos de sucessivas sessões de aspirações foliculares na quantidade, qualidade e capacidade de maturação in vitro de oócitos obtidos de ovelhas submetidas à estimulação hormonal prévia (80 mg FSH + 300 UI eCG). Foram selecionadas seis ovelhas (n=6) da raça Santa Inês, as quais foram submetidas a nove sessões de aspiração folicular por vídeolaparoscopia com intervalo de sete dias, totalizando 56 aspirações. Ao final do período de cultivo de 24 horas, os oócitos foram corados e classificados quanto ao estádio de maturação nuclear e citoplasmática. A taxa de recuperação foi de 61,4±2%, observando-se ausência de variação entre as sessões (p>0,05), e a média de oócitos recuperados por fêmeas de 6,4±2 por semana, com um total de 249 oócitos recuperados, sendo a média de 42±4 oócitos por fêmea no total das apirações. Não houve diferença significativa entre a classificação da maturação nuclear (p=0,937), mas sim entre a maturação citoplasmática (p<0,0001), entretanto não foi observado variação estatística entre as semanas quanto a maturação nuclear (p=0,908) e a maturação citoplasmática (p=0,792). Concluímos que após nove sessões consecutivas de aspiração folicular o número e a qualidade dos oócitos recuperados permaneceram constantes assim como as taxas obtidas de maturação nuclear e citoplasmática, demonstrando a viabilidade desta técnica para repetidas aspirações foliculares em uma mesma doadora / The success of in vitro production requires an effective collection technique as well as an efficient oocyte recovery. In addition, the best results have been applied for using laparoscopic aspiration. The aim of the present study was to evaluate if successive follicle aspiration sessions may interfere on quantity, quality and in vitro maturation of oocytes recovery from ewes submitted to hormonal stimulation. Santa Ines ewes (n=6) were submitted to a total of nine sessions (one session per week) of follicle aspiration performed by videolaparoscopy. The oocytes from each session were classified in according to quality and to in vitro maturation capacity. Nuclear and citoplasmatic maturation were assessed. The recovery rate was 61,39±19,97%, with no variation among the sessions (p>0,05) and the mean of recovered oocytes per ewe was 6,36±2,0 per week. There was no significant difference among nuclear maturation classification (p=0,937), but there was significant difference among citoplasmatic maturation (p<0,0001). There was no statistical variation among weeks to nuclear maturation (p=0,908), neither to citoplasmatic maturation (p=0,792). We could conclude that after nine consecutive sessions of follicle aspiration the number and quality of the recovery oocytes were constant, as well as nuclear and citoplasmatic maturation rates. Therefore, laparoscopic recovery of oocytes is a viable technique for repeated follicle aspiration in the same donor