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Transcriptomic Signatures of Heart Failure in People Living with HIVFang, Mike 22 January 2021 (has links)
No description available.
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COMPARATIVE BIOINFORMATIC AND MOLECULAR EVOLUTIONARY ANALYSIS OF CHORDATE GENES AND GENOMESNorthover, David, 0000-0003-2889-1098 January 2020 (has links)
As knowledge of evolutionary processes has expanded over the years, we havedeepened our understanding about how they drive organismal, cellular, and molecular
biology and the factors beyond natural selection that are involved. Nevertheless, selection
maintains a role in fixing and maintaining successful adaptations to new niches, whether
from environmental change or organismal migration. Adaptation should not be considered
solely on the level of individual genes and point substitutions as selection occurs on multiple
levels. Examination on these multiple levels can further aid in understanding the constraints
on evolution and how organisms can attain a phenotype.
Here we present two packages of tools for the examination of selection on the
levels of protein structure and genetic pathways as well as on the individual gene and
sequence levels., followed by examples of potential applications. First, we present a
package of Application Programming Interface (API) tools that simplifies use of The Adaptive
Evolutionary Database. Second, we present a package of tools implemented in the Rust
programming language for fast and reliable analysis of phylogenetic data.
Then we describe the phenotypic data and methodology for use of these tools to
analyze evolution on multiple levels, where genomic data is available. A broad scale analysis
of the protein structural properties of evolutionary genetic changes in proteins is developed
and described. We also present an organization of phenotypic data for mammals in the
arctic biome, an ancestral reconstruction of the evolution of the phenotypic traits under
study, and demonstrate a methodology to apply the tool packages to this cohort when
sufficient genomic data is available. / Biology / Accompanied by two compressed .zip files: 1) Titled Charts 2) Appendices
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Bioinformatic sequence and structural analysis for Amyloidogenicity in Prions and other proteinsGendoo, Deena January 2012 (has links)
No description available.
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234 |
Coevolution of transposable elements and plant genomes by DNA sequence exchangesHoen, Douglas January 2012 (has links)
No description available.
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235 |
Molecular pathway analysis of mouse models for breast cancerLesurf, Robert January 2009 (has links)
No description available.
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236 |
Bioinformatics for epigenomicsCingolani, Pablo January 2009 (has links)
No description available.
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237 |
Implications of host ULP1-like domains in DNA transposonsSabry, Nadia Hesham January 2010 (has links)
No description available.
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238 |
Predicting transcription factor binding sites using phylogenetic footprinting and a probabilistic framework for evolutionary turnoverParmar, Victor January 2010 (has links)
No description available.
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239 |
Computational DNA motif discovery in plant promotersFauteux, François January 2010 (has links)
No description available.
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240 |
A systems approach towards a functional annotation of the genome of Trypanosoma bruceiShateri Najafabadi, Hamed January 2012 (has links)
No description available.
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