Global ETD Search

281	Spiral irradiation in stereotactic radiosurgery Dubé, Frédéric, 1973- January 1999 (has links) No description available. Physics, Radiation. Health Sciences, Medicine and Surgery. Biophysics, Medical. Health Sciences, Radiology.
282	Radiosensitization of a mouse tumor model (RIF-1) by Bromodeoxyuridine (BrdU) using biodegradable polymer implants as a controlled drug delivery system Doiron, Annie. January 1997 (has links) No description available. Biophysics, Medical. Health Sciences, Radiology. Health Sciences, Pharmacology. Health Sciences, Oncology.
283	Folding of the Prion Protein Apetri, Constantin Adrian 31 March 2004 (has links) No description available. Biophysics, Medical protein folding prion diseases prion protein folding intermediate salt effect kinetics stopped flow
284	Lysosomal Regulation of Gene Expression Heur, J. Martin 27 September 2002 (has links) No description available. Biophysics, Medical lysosome M-CSF lysosomal acid lipase macrophage PPAR&947
285	ENDOGENOUS AND EXOGENOUS SOURCES OF CHOLESTEROL DURING FETAL DEVELOPMENT SCHMID, KARA E. 02 September 2003 (has links) No description available. Biophysics, Medical fetal cholesterol metabolism placental transport cholesterol synthesis Smith-Lemli-Optiz
286	Dynamics of Dressed Neurons: Modeling the Neural-Glial Circuit and Exploring its Normal and Pathological Implications Nadkarni, Suhita 03 November 2005 (has links) No description available. Biophysics, Medical Astrocyte Neuron Interaction Modeling Neural Glial Circuits Astrocytes Neurons Metabotropic Glutamate Receptors
287	Tau and alpha-synuclein fibrillization in vitro: lessons from surfactant inducers and small molecule inhibitors Necula, Mihaela 29 September 2004 (has links) No description available. Biophysics, Medical Alzheimer&8217 s disease, Parkinson&8217
288	Synthesis, characterization, microfabrication and biological applications of conducting polymers Yang, Yanyin 10 October 2005 (has links) No description available. Biophysics, Medical Bone cell growth Conducting polymers Electrical Stimulation Interdigitated electrodes
289	Regulation of cardiac voltage gated potassium currents in health and disease Sridhar, Arun 24 August 2007 (has links) No description available. Biophysics, Medical Potassium Currents Sudden Cardiac Death Heart Failure Atrial Fibrillation Ion Current Ion Channel
290	Biophysical characterization of branched amphiphilic peptide capsules and their potential applications in radiotherapy Sukthankar, Pinakin Ramchandra January 1900 (has links) Doctor of Philosophy / Department of Biochemistry and Molecular Biophysics / John M. Tomich / Branched Amphiphilic Peptide Capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble in water to form bilayer delimited poly-cationic capsules capable of trapping solutes. We examined the lipid-like properties of this system including assembly, fusion, solute encapsulation, and resizing by membrane extrusion as well as their capability to be maintained at a specific size by storage at 4˚C. These studies along with earlier work from the lab (Gudlur et al. (2012) PLOS ONE 7(9): e45374) demonstrated that the capsules, while sharing many properties with lipid vesicles, were much more robust. We next investigated the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs. We demonstrated that the BAPCs are readily taken up by epithelial cells in culture, escape or evade the endocytotic pathway, and accumulate in the peri-nuclear region where they persist without any apparent degradation. The stability and persistence of the capsules suggested they might be useful in delivering radionuclides. The BAPCs encapsulated alpha particle emitting radionuclides without any apparent leakage, were taken up by cells and were retained for extended periods of time. Their potential in this clinical application is being currently pursued. Lastly we studied the temperature dependence of capsule formation by examining the biophysical characteristics of temperature induced conformational changes in BAPCs and examined the structural parameters within the sequences that contribute to their remarkable stability. A region in the nine-residue sequence was identified as the critical element in this process. The ability to prepare stable uniform nano-scale capsules of desired sizes makes BAPCs potentially attractive as delivery vehicles for various solutes/drugs. BAPCs Radiotherapy Alpha particle Nanocapsules Drug delivery Peptide Biochemistry (0487) Biophysics (0786) Biophysics, Medical (0760) Chemistry (0485) Chemistry, Radiation (0754)

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