The Minnesota Multiphasic Personality Inventory (MMPI) is the most frequently used psychological measure in the assessment of chronic pain. Since the introduction of the MMPI-2 in 1989 only two published studies have focused on cluster analysis of chronic pain patients. This study investigated MMPI-2 cluster solutions of chronic low-back pain patients. Data was collected from 2,051 chronic low-back pain patients from a multidisciplinary pain clinic in the southwestern United States. A hierarchical clustering procedure was performed on K-corrected T-scores of the MMPI-2 using the three validity and ten clinical scales. Four relatively homogeneous subgroups were identified for each sex with the MMPI-2. In general, these results replicated the findings of previous researchers using both the MMPI and MMPI-2.

This study examined the effects of self-monitoring behavior and health locus of control on improvement in a work hardening program. The subjects included 22 male and 18 female outpatients in a hospital-based rehabilitation program. Subjects were classified as having an internal or external health locus of control, and were randomly assigned to either a self-monitoring or a non-self-monitoring group. Improvement was assessed via objective performance data and self-ratings of perceived improvement. The results indicated that individuals identified as having an internal health locus of control did not show greater gains in physical functioning or perceived improvement relative to externally oriented individuals. Additionally, those subjects participating in self-monitoring activities were no different from non-self-monitoring subjects in terms of improvement in exercise activities or perceived improvement. The results also indicated no interaction between health locus of control and the presence or absence of self-monitoring. It was suggested that other factors such as workman's compensation, pain patient characteristics, low self-concept, and severe stress may have proved more powerful influences on patient improvement than internal health locus of control or self-monitoring. It was also suggested that rehabilitation programs might benefit from creating structured environments in which patients receive frequent staff feedback and reinforcement for improvement. Monitoring small, discrete, easily attainable goals might prove more effective than monitoring mood, pain, etc. In addition, teaching specific internal health locus of control behaviors to patients may help them improve their self-concepts and progress. Further research is needed to explore the roles that pain patient personality characteristics, self-concept, and stress play in the progress of patients in a work hardening program.

In today's health care environment tremendous efforts are being made by Health Maintenance Organizations (HMOs) to deliver appropriate patient care while controlling utilization of services and costs. One area of concern over the past two years has been the apparent over-utilization of spinal surgeries within a local Senior HMO. This HMO has no specific plan or physician guidelines for the management of low back pain. Utilization of spinal surgeries is measured in incidence of admissions per thousand members of the Senior HMO. Over the past two years the incidence of spinal surgeries per thousand has grown from 2.4 in 1995, 4.1 in 1996 and 7.4 during the first quarter of 1997. This is compared to a suggested rate of 1.5 per thousand for similar HMO populations around the country. The purpose of this study was to determine the effectiveness of the presentation of a treatment algorithm and physician guidelines for the management of low back pain (LBP). In order to determine the effectiveness of the presentation of the algorithm, the incidence of spinal surgeries per thousand for nine quarters prior to the presentation was compared to the incidence per thousand for the three quarters following the presentation. Results of this comparison showed a slight drop, but statistically insignificant (P = .62), in the rate of surgeries compared to the previous year. When compared to the previous two years the rate was actually slightly higher, but statistically insignificant (P = .57) after the presentation. Although the comparisons were determined to be insignificant, trend analysis indicated a gradual rise in the incidence during the initial five quarters, a plateau during the next four quarters, and a slight decrease in the rate of surgeries during the last three quarters which followed the introduction of the treatment algorithm. At this time it would be appropriate to continue the analysis of quarterly data and continue feedback and education to the primary care physicians in an attempt to promote proper utilization of spinal surgeries and overall management of LBP.

Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP) worldwide which is expected to affect 80% of the world’s population. IVD degeneration (IDD) is a key player in the degenerative cascade associated with LBP. Pro-inflammatory cytokines and mediators, such as nitric oxide, have been shown to be triggers and mediators of IDD. Due to the avascular nature of the adult IVD, the disc is unable to heal or regenerate when damaged. The multi-components of the IVD, namely glycosaminoglycan (GAG)-rich nucleus pulposus (NP), a concentric collagen dense annulus fibrosis (AF), and cartilage endplates (CEPs), further complicate possible regenerative solutions. Cell therapies show promise. This is supported by studies that demonstrate the use of mesenchymal stem cells (MSCs) in animal models showing potential in mitigating inflammatory signaling as well as recovering proteoglycan content. Despite these promising findings, several gaps in knowledge remain. While the biochemical and mechanical properties of an injured disc (via physical or chemical stimulation) have been characterized, the resulting inflammatory signaling cascades remain undefined. A growing body of evidence suggests that TLR4 is involved in the pathogenesis of the IVD. However, it is unknown how TLR4 mediates injury responses of the IVD. Second, it is unknown how mechanical loading of IVDs can influence the transcriptome or secretome of the IVD. The IVD is normally exposed to multimodal loading (e.g., compression, tension, shear, hydrostatic pressure, and osmotic pressure). Both frequency and magnitude regulate whether loading is beneficial or detrimental to disc integrity, which will be explored. Furthermore, the secretome of the IVD, especially during loading, may be essential to creating therapies targeted for regeneration of the IVD. There may be key, distinct paracrine factors that are released in IVD conditioned loading media which can influence the regenerative and anti-inflammatory capabilities of cell-based therapies. To address these gaps, this thesis describes a series of experiments employing novel ex vivo organ culture model to study the response of the IVD to various injury modalities (inflammatory stimulation, puncture injury, compressive loading), and resulting changes in inflammatory, biomechanical, and biochemical responses. Through methods such as RNA sequencing and proteomics, we now have expanded the characterization to beyond candidate genes or proteins, and are more informed on (1) the IVD response to injury, (2) the role of TLR4 signaling in this ex vivo organ culture model, in addition to (3) the downstream effects of loading and how paracrine factors can be used to improve and develop potential cell and molecular therapies. Sex-based differences, in male and female rat caudal IVDs, were also identified and are analyzed in the context of response to injury.

M.Tech. / OBJECTIVE: To determine the most effective treatment protocol in the treatment of Lower-Crossed Syndrome by comparing objective results gained from a Rehabilitation program (group one), Spinal Manipulative Therapy (group two) and a combination of these therapies (group three) directed at the sacroiliac joints and lumbar spine. DESIGN: The study was a clinical trial in which three experimental groups of sixteen participants each were compared to each other. These participants were recruited from the local general population and were selected on the basis of inclusion and exclusion criteria, presenting with Lower-Crossed Syndrome and demonstrating unremarkable clinical and radiological findings. INTERVENTION AND DURATION: After randomisation, group one received a Rehabilitation program which consisted of a stretching and strengthening program only, group two received Spinal Manipulative Therapy only whereas group three received a combination of Spinal Manipulative Therapy and a Rehabilitation program. The frequency of the follow up consultations for this study was two consultations over the first two weeks of the trial and once a week for the following four weeks of the trial. MEASUREMENTS: Objective measurements included lumbar spine flexion and extension ranges of motion, hip flexor flexibility (hip extension), active and passive hamstring flexibility, gluteus maximus and abdominal strength tests and Sorenson’s Test (static back extensor strength test). Subjective measurements were the Oswestry Low Back Pain and Disability Index and McGill’s Questionnaire. Measurements were taken before (pre-) and after (post-) the first (initial), third, fifth and eighth (last) consultations. CONCLUSIONS: The aim of the study was to determine the most effective treatment protocol in the management of Lower Back Pain in athletes presenting with Lower-Crossed Syndrome. Although the combined group (group three) showed the greatest improvement these findings were statistically no greater than the statistical findings in group one and group two. All groups showed a statistically significant improvement over the trial period. This illustrates that both Spinal Manipulative Therapy and a Rehabilitation program (including stretching and strengthening) was effective in the management of Lower-Crossed Syndrome. From this study it can therefore be concluded that one treatment protocol did not prove to be more effective than that of the others.

Chronic pain sufferers are frequently misunderstood and stigmatised. The aim of this investigation was to provide a description of the lifewor1d of people with chronic low back pain, using the phenomenological method. Themes which emerged were that the persistent nature of chronic pain makes it particularly difficult to endure, arousing a profound fear of the future. It causes a disruption in the relationship between the person and the body, in which the person is forced to function within the constraints of pain. Sufferers are unable to fulfil social roles as expected and are forced to revise their goals and activities. The distress of their experience is mediated by the ability to make sense of their condition, finding meaning in the pain itself. The study highlights the value of the phenomenological method in health psychology. Recommendations are made which may be of benefit to people with chronic pain and their families. / Psychology / M. Sc. (Psychology)

Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban University of Technology, 2007 xi, 38 leaves, Annexures 1-2 / Background: Various congenital spinal anomalies are common findings in the general population. Their clinical significance is controversial with no definitive association been made between any specific congenital spinal anomaly to any clinical features. Project Design: This research study was designed in the form of a quantitative, non-experimental, empirical clinical survey. Method: Data was obtained from thoracic and lumbar spine radiographs contained in the Chiropractic Day Clinic at the Durban University of Technology from 1 January 1997 to 31 December 2005 and from the corresponding patient files. Through the research procedure, 519 thoracic and lumbar spine radiographs were located in the confines of the Chiropractic Day Clinic. Due to the exclusion criteria of a past or present history of trauma to the thoracic or lumbar spine areas, 147 radiographs were excluded. Objectives 1.To determine the period prevalence (1 January 1997 – 31 December 2005) of congenital thoracic and lumbar spine anomalies. 2.To determine if there is any association between the presenting clinical features and the congenital thoracic and lumbar spine anomalies in general. 3.To determine if there is any association between the presenting clinical features and individual congenital thoracic and lumbar spine anomalies. 4.To compare subjects presenting clinical features with reported clinical features from literature.

Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban University of Technology, 2007 xi, 61 leaves, Annexures A-E, 1-5 / Research is more than merely an academic exercise. It is a key ingredient in establishing chiropractic’s role in an evolving health care system (Dallas, 1997). Very little is known about the changes in the chiropractic patient population over time (Hartvigsen et al. 2003). Despite the widespread use of chiropractic, good descriptive data on chiropractors and their patients are limited (Coulter and Shekelle, 2005). Few studies have been reported which deal specifically with patients attending chiropractic teaching clinics (Nyiendo and Olsen, 1988). A teaching clinic is an outpatient clinic that provides health care for patients, as opposed to inpatients treated in a hospital. Teaching clinics are traditionally operated by educational institutes and provide free or low-cost services to patients (http://en.wikipedia.org/wiki/Teaching_clinic). In April 1994 the chiropractic day clinic was officially opened at the former Technikon Natal (now the Durban University of Technology). Thousands of patients have been treated at this clinic over this twelve year period. In 1994, Elga Renate Drews, conducted research aimed at identifying characteristics of chiropractic patients and their complaints at the chiropractic teaching clinic at Technikon Natal and private practices in South Africa. This survey was conducted from February 1994 to the end of April 1994. 162 Patients were involved in this study. A survey was completed which included the patient’s age, gender, occupation, presenting condition, duration of complaint, previous treatment, referral, severity, quality of pain and their disability. A comparison was made between patients seen in private practice and at the teaching clinic. It was found that generally both populations were very similar, with the exception of the patients’ age and occupation. No other research investigating patient characteristics has been undertaken at Durban University of Technology chiropractic day clinic after 1994. Furthermore, in the study conducted by Drews no mention was made of the type of treatment that was given to patients either in private practice or at the teaching clinic. Although the first successful chiropractic adjustment recorded was in the thoracic spine by Dr. D.D. Palmer, research since then has focused on the lumbar spine (Di Fabio, 1992). In reviewing literature relating to the thoracic spine, it is apparent that in comparison to the cervical and lumbar regions, the thoracic spine has been neglected (Edmonston and Singer, 1997). In South Africa there remains a paucity of information on the types of thoracic conditions chiropractors treat and the management protocols. The present research aimed to shed light on this aspect by collecting data from one of only two chiropractic teaching clinics in South Africa, namely the Durban University of Technology chiropractic day clinic. The purpose of this research was to investigate the age, gender, occupation (whether of a sedentary or non-sedentary nature), prevalence of pain, presenting complaints, common conditions treated and common management protocols of patients who presented with thoracic pain to the Durban University of Technology Chiropractic Day Clinic.

Thesis (M.Tech.:Chiropractic)-Dept. of Chiropractic, Durban University of Technology, 2007 xiii, 76, 13 leaves / To determine the prevalence and demographics of lumbo-sacral cases recorded at the D.U.T Chiropractic Day Clinic from 13th January 1995 to 30th November 2005. To identify the aetiology, common lumbo-sacral diagnoses, associated signs and symptoms, management and contra-indications to chiropractic treatment recorded on the initial consultation of patients with lumbo-sacral complaints.

Thesis (M.Tech.: Chiropractic)-Dept. of Chiropractic, Durban University of Technology, 2007 xi, 60 leaves, Annexures 1-9 / The Transversus Abdominis (TrA) muscle is recognised in the literature as playing a vital and protective role in maintaining a healthy core and aiding lumbar biomechanics in the dampening of external forces applied to the lumbar spine. Pilates purports to employ the principles of core training yet there remains a deficit in the literature despite its popularity in rehabilitation and fitness industries. This study aimed to evaluate the efficacy of Pilates method in training the TrA in comparison to a moderately active population that regularly exercises in a gym environment, as well as a sedentary control.