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Bacteriophages, regarded today as viruses parasitic on bacteria, are characterized by a number of well-defined properties, one of these being the specificity exhibited by some varieties of phages, not only for a single species of bacteria, but also for certain strains or types of that single species. A practical application of this property has been the use of bacteriophage for the identification or phage typing of certain strains of a given species. Fisk (1942) introduced a method of phage typing of staphylococci which has been successfully used for tracing sources of infection in epidemic outbreaks of staphylococcal enterotoxin food-poisoning and of staphylococcal infections of the skin in babies in maternity hospitals. Although this method is relatively simple and rapid, many strains of staphyloccoi are resistant to the action of the available phages and the absolute specificity of the phage types is questionable. The purpose of this work is to investigate the growth and multiplication requirements and the stability of the staphylococcus bacteriophages now available, and to use anti-bacteriophage sera (prepared by immunizing rabbits with selected phage strains) as a means for recognition of specificity. If the phages could be divided into a few representative groups, it is hoped that by a careful selection of these phages, a simpler method of phage typing applicable in every laboratory may be developed.

Since the advent of improved tissue culture techniques the study of animal viruses has made rapid progress. The effect of a virus infection on the host cells has been studied from many aspects. One aspect is the alteration of the protein synthetic capacities of the infected cells. Many studies have been performed on the proteins of the virus particle such as the antigens and the haemagglutinins, or the proteins of the cells, such as the enzymes used to synthesize the virus particles. Little attention has been paid to the cellular proteins which were not involved in the synthesis of the virus particle. Such a protein is antibody. The following report shows how the metbod was establisbed for the quantitation of antibody produced in vitro. It will examine the effect of Newcastle disease virus on the immunologically competent cells in spleen cell suspensions. [...]