The bacteriophage T4 utilizes at least three modes of initiation of replication, termed primary, secondary and tertiary (Mosig, 1983; Kreuzer and Alberts, 1985). Two origins of replication have been isolated that utilize the tertiary mode of initiation. The DNA sequence requirements of the two tertiary origins have been characterized at the nucleotide level. Maximal replication of each origin-containing plasmid required both an intact gpmotA-dependent middle-mode promoter sequence and approximately 50 basepairs of the downstream region. In contrast, gpmotA-dependent transcription from the origin promoter was found to be independent of the downstream region. The requirement for a promoter element within the tertiary origins is striking, particularly since the replication of tertiary origin-containing plasmids is resistant to the RNA polymerase inhibitor rifampicin.

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xiv, 131 leaves : ill. ; 28 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 1975

Thesis (Ph.D.) -- University of Adelaide, Department of Biochemistry, 1975.

Thesis (M.S.)--Bowling Green State University, 2008. / Document formatted into pages; contains x, 75 p. : ill. Includes bibliographical references.

Thesis (Ph. D.)--University of Texas at Austin, 2002. / Vita. Includes bibliographical references. Available also from UMI Company.

Thesis (M.S.)--University of Toledo, 2004. / Typescript. "A thesis [submitted] as partial fulfillment of the requirements of the Master of Science degree in Chemistry." Bibliography: leaves 111-112.