Thesis (Ph. D.)--University of Wisconsin, 1964. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Bibliography: leaves 135-148.

Thesis (M.S.)--University of Michigan, 1952.

Antagonistic inotropic actions of barbiturates and adrenergic amines have, been demonstrated in dog hearts. The present work was undertaken to ascertain whether a similar antagonism occurred in other tissues, and if so, how specific and potent it is. The tissues selected for studying these phenomena were rabbit kidney cortex slices, uterine horns of previously estrogenized rabbits and guinea pig terminal ileum. The tone and contractility of the isolated smooth muscle preparation and the active transport of sodium para-aminohippuric acid (PAH) by the kidney cortex slices, were the processes monitored. No antagonism of the barbiturate induced depression of the active uptake of PAH by kidney cortex slices on the part of adrenergic amines was observed. Only a weak antagonism between these two groups of drugs was evident under suitable conditions in the guinea pig ileum. However, in contrast to these observations, a potent antagonism similar to that demonstrated in the dog hearts, was evident in the rabbit uterine horns. The experimental data indicated that adrenergic amines and barbiturates are antagonistic only in those tissues where barbiturates depress and adrenergic amines stimulate the energy utilizing process studied. The antagonism when evident is not specific and may be classified as independent or physiological. / Medicine, Faculty of / Anesthesiology, Pharmacology and Therapeutics, Department of / Graduate

No description available.

Thesis (M.S.)--University of Michigan, 1951.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1931. / Typescript. With this are bound: The intravenous use of the barbituric acid hypnotics in surgery / Richard H. Fitch, Ralph M. Waters, and Arthur L. Tatum. Reprinted from American journal of surgery, new series, vol. IX, no. 1 (July 1930), p. 110-114 -- An experimental study of tolerance to barbiturates / by Richard H. Fitch. Reprinted from Journal of pharmacology and experimental therapeutics, vol. XXXIX, no. 3 (July 1930) -- Picrotoxin as an antidote in acute poisoning by the shorter acting barbiturates / by A.H. Maloney, R.H. Fitch and A.L. Tatum. Reprinted from Journal of pharmacology and experimental therapeutics, vol. XLI, no. 4 (Apr. 1931), p. 465-482. Includes bibliographical references.

No description available.

Thesis--University of Florida. / Description based on print version record. Typescript. Includes bibliographical references (leaves 100-105).

This study involves compounds of the barbituric acid series are well known for their use as anesthetics and sedatives.

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