The Mississippi River Bridge in Vicksburg, MS is a 7 span cantilever bridge that is 3,389 feet long by 68.5 feet wide and is part of the Interstate-20 corridor. On March 23, 2011 at 1:30pm, a barge moving downstream struck a pier of the bridge. Infrasound stations located at the U.S. Army Engineer Research and Development Center (ERDC) detected the impact. Coincidentally, ERDC had instrumented the bridge with strain gages and accelerometers as part of a structural health monitoring project. Finite Element (FE) models were developed to investigate the structural behavior of the bridge due to the impact. The measurements and the FE models were used to determine the source mechanism of the infrasound from the bridge. Measurements from the sensors that were installed on the bridge will be presented along with FE models and infrasound data.