by Yeung Yuk-Ching. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (leaves 119-129). / Abstracts in English and Chinese. / Abstract in English --- p.ii / Abstract in Chinese --- p.v / Glossary --- p.viii / Acknowledgements --- p.x / Publications Arising From this Thesis --- p.xii / List of Tables --- p.xviii / List of Figures --- p.xix / Chapter 1 --- INTRODUCTION --- p.1 / Chapter 1.1 --- Definition of Heart Rate Variability --- p.1 / Chapter 1.2 --- Physiology --- p.1 / Chapter 1.2.1 --- Review of Autonomic Nervous System and Influence of Heart Rate --- p.1 / Chapter 1.2.2 --- The Role of Baroreceptors in the Control of Circulation --- p.4 / Chapter 1.2.3 --- The Control and Physiological Importance of Heart Rate --- p.7 / Chapter 1.2.3.1 --- Normal Heart Rate --- p.7 / Chapter 1.2.3.2 --- Autonomic Control of Heart Rate --- p.8 / Chapter 1.2.3.2.1 --- Sympathetic Effects --- p.8 / Chapter 1.2.3.2.2 --- Vagal Effects --- p.8 / Chapter 1.2.3.3 --- Reflexes Influencing Heart Rate --- p.9 / Chapter 1.2.3.3.1 --- Baroreceptors --- p.10 / Chapter 1.2.3.3.2 --- Chemoreceptors --- p.10 / Chapter 1.2.3.3.3 --- Atrial Receptors --- p.11 / Chapter 1.2.3.3.4 --- Coronary Chemoreflex --- p.11 / Chapter 1.2.3.3.5 --- Other Reflexes --- p.12 / Chapter 1.2.3.4 --- Influence of Complex Events on Heart Rate --- p.12 / Chapter 1.2.3.4.1 --- Respiratory Influence --- p.12 / Chapter 1.2.3.4.2 --- Effects of Decreases in Venous Return --- p.13 / Chapter 1.2.3.4.3 --- Exercise --- p.13 / Chapter 1.2.3.5 --- Physiological Importance of Heart Rate --- p.14 / Chapter 1.3 --- Spectral Analysis of Blood Pressure and Heart Rate Variability in Evaluating Cardiovascular Regulation --- p.14 / Chapter 1.4 --- Clinical Relevance --- p.15 / Chapter 1.4.1 --- Increased Sympathetic Activity --- p.15 / Chapter 1.4.2 --- Reduced Parasympathetic Activity --- p.15 / Chapter 1.4.3 --- Low Heart Rate Variability --- p.16 / Chapter 1.4.4 --- Depressed Baroreflex Sensitivity --- p.17 / Chapter 1.4.5 --- Prognostic Value of Heart Rate Variability in Disease States --- p.17 / Chapter 1.4.6 --- Abnormality of Autonomic Nervous System in Heart Failure --- p.17 / Chapter 2 --- METHODS FOR ASSESSING HEART RATE VARIABILITY --- p.20 / Chapter 2.1 --- Time Domain Analysis of Heart Rate Variability --- p.20 / Chapter 2.1.1 --- Statistical Methods --- p.21 / Chapter 2.1.2 --- Geometric Methods --- p.22 / Chapter 2.2 --- Spectral Analysis of Heart Rate Variability --- p.23 / Chapter 2.3 --- "Nonlinear Indices (fractal, entropy, chaos theory)" --- p.27 / Chapter 3 --- HEART FAILURE --- p.28 / Chapter 3.1 --- Heart Rate Variability in Heart Failure --- p.28 / Chapter 3.2 --- Effect of Changes in Respiratory Frequency and Posture on Heart Rate Variability Analysis in Heart Failure --- p.34 / Chapter 3.3 --- Effect of Respiratory Rates on Baroreceptor Function in Heart Failure --- p.34 / Chapter 3.4 --- Effect of Treatment on Heart Rate Variability in Heart Failure Patients --- p.35 / Chapter 4 --- AIMS --- p.39 / Chapter 4.1 --- Effect of Changes in Respiratory Frequency and Posture on Heart Rate Variability --- p.39 / Chapter 4.2 --- Effect of Slow Breathing --- p.39 / Chapter 4.3 --- Effect of Therapeutic Interventions in Chronic Heart Failure --- p.39 / Chapter 4.3.1 --- A Comparison of Celiprolol with Metoprolol --- p.39 / Chapter 4.3.2 --- A Comparison of Carvedilol with Metoprolol --- p.40 / Chapter 5 --- STUDIES --- p.41 / Chapter 5.1 --- Impact of Changes in Respiratory Frequency and Posture on Power Spectral Analysis of Heart Rate and Systolic Blood Pressure Variability in Normal Subjects and Patients with Heart Failure --- p.41 / Chapter 5.1.1 --- Subjects --- p.41 / Chapter 5.1.2 --- Recording Technique and Protocol --- p.42 / Chapter 5.1.3 --- Signal Acquisition --- p.42 / Chapter 5.1.4 --- Power Spectral Analysis --- p.43 / Chapter 5.1.5 --- Statistical Analysis --- p.46 / Chapter 5.1.6 --- Results --- p.46 / Chapter 5.1.7 --- Discussion --- p.52 / Chapter 5.1.8 --- Summary --- p.56 / Chapter 5.2 --- Slow Breathing Increases Arterial Baroreflex Sensitivityin Patients with Chronic Heart Failure --- p.57 / Chapter 5.2.1 --- Subjects --- p.57 / Chapter 5.2.2 --- Assessment of Baroreflex Sensitivity --- p.57 / Chapter 5.2.3 --- Statistical Analysis --- p.58 / Chapter 5.2.4 --- Results --- p.59 / Chapter 5.2.5 --- Discussion --- p.62 / Chapter 5.2.6 --- Summary --- p.63 / Chapter 5.3 --- β-Blockers in Heart Failure: a Comparison of a Vasodilating β- Blocker with Metoprolol on Heart Rate Variability by 24 Hour ECG Recordings (Time-Domain & Spectral Analysis) --- p.65 / Chapter 5.3.1 --- Trial Design --- p.65 / Chapter 5.3.2 --- Study Patients --- p.65 / Chapter 5.3.3 --- Study Measurements --- p.66 / Chapter 5.3.4 --- Statistical Analysis --- p.67 / Chapter 5.3.5 --- Results --- p.67 / Chapter 5.3.6 --- Discussion --- p.80 / Chapter 5.3.7 --- Summary --- p.81 / Chapter 5.4 --- Effect of β-Blockade on Baroreceptor and Autonomic Function in Heart Failure-Assessment by Short Term Spectral Analysis --- p.83 / Chapter 5.4.1 --- Trial Design and Study Patients --- p.83 / Chapter 5.4.2 --- Recording Technique and Protocol --- p.83 / Chapter 5.4.3 --- "Signal Acquisition, Power Spectral Analysis and Cross Spectral Analysis" --- p.83 / Chapter 5.4.4 --- Reproducibility --- p.84 / Chapter 5.4.5 --- Statistical Analysis --- p.84 / Chapter 5.4.6 --- Results --- p.84 / Chapter 5.4.7 --- Discussion --- p.93 / Chapter 5.4.8 --- Summary --- p.97 / Chapter 5.5 --- β-Blockade in Heart Failure: A Comparison of Carvedilol with Metoprolol on HRV by 24 hour ECG Recordings (Time-Domain & Spectral Analysis) --- p.98 / Chapter 5.5.1 --- Trial Design and Patient Demographics --- p.98 / Chapter 5.5.2 --- Study Measurements --- p.98 / Chapter 5.5.3 --- Statistical Analysis --- p.99 / Chapter 5.5.4 --- Results --- p.99 / Chapter 5.5.5 --- Discussion --- p.105 / Chapter 5.5.6 --- Conclusions --- p.107 / Chapter 5.6 --- Comparison of Carvedilol and Metoprolol on Baroreceptor Gain in Heart Failure by Short Term Spectral Analysis --- p.108 / Chapter 5.6.1 --- Study Design --- p.108 / Chapter 5.6.2 --- Study Patients --- p.108 / Chapter 5.6.3 --- Recording Technique and Protocol --- p.108 / Chapter 5.6.4 --- "Signal Acquisition, Power Spectral Analysis and Cross Spectral Analysis" --- p.108 / Chapter 5.6.5 --- Statistical Analysis --- p.109 / Chapter 5.6.6 --- Results --- p.109 / Chapter 5.6.7 --- Discussion --- p.112 / Chapter 5.6.8 --- Summary --- p.112 / Chapter 6 --- "GENERAL DISCUSSION, LIMITATIONS & CONCLUSIONS" --- p.113 / Chapter 6.1 --- Discussion --- p.113 / Chapter 6.2 --- Conclusions --- p.117 / Chapter 7 --- REFERENCES --- p.119

Chen Fei. / "October 2004." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references. / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.