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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"basal ganglia diseases animal models"" "subject:"basal ganglia diseases 1animal models""

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Biconditional discrimination learning in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis

Kitto, Michael Ryan 01 January 2006 (has links)
The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.
Alzheimer's disease Animal models
Basal ganglia Diseases Animal models
Learning disabilities
Memory disorders
Rats Physiology
Alzheimer's disease Animal models
Learning disabilities
Memory disorders
Rats Physiology.
Biological Psychology

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