The Berea Sandstone is a Late Devonian, tight oil and gas reservoir that intertongues with the Bedford Shale in eastern Kentucky. In order to evaluate the Bedford-Berea interval in the subsurface, 555 well logs from the Kentucky Geological Survey’s oil and gas database were used to construct structure maps, isopach maps, and cross sections of the interval and its possible hydrocarbon source rocks. Gamma-ray logs were compared to known cores in order to separate Bedford from Berea lithologies. Maps and cross sections were compared to known basement structures to evaluate possible structural influences on the interval. The Bedford-Berea interval is thickest along a north-south elongate trend which extends from Lewis to Pike Counties and cuts across basement structures. Along this trend, the interval is thickest and the percentage of Berea lithologies is greatest on known basement highs. The interval is thinnest and dominated by Bedford shales above structural lows and west of the main trend. Several wells are also reported in which the Bedford-Berea thickens on the down-thrown side of major faults. Also, in northeastern Kentucky, where the Berea is thickest, possible submarine channel facies are identified which cut into the underlying Cleveland Shale near the Waverly Arch.