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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Neural mechanisms of suboptimal decisions

Chau, Ka Hung Bolton January 2014 (has links)
Making good decisions and adapting flexibly to environmental change are critical to the survival of animals. In this thesis, I investigated neural mechanisms underlying suboptimal decision making in humans and underlying behavioural adaptation in monkeys with the use of functional magnetic resonance imaging (fMRI) in both species. In recent decades, in the neuroscience of decision making, there has been a prominent focus on binary decisions. Whether the presence of an additional third option could have an impact on behaviour and neural signals has been largely overlooked. I designed an experiment in which decisions were made between two options in the presence of a third option. A biophysical model simulation made surprising predictions that more suboptimal decisions were made in the presence of a very poor third alternative. Subsequent human behavioural testing showed consistent results with these predictions. In the ventromedial prefrontal cortex (vmPFC), I found that a value comparison signal that is critical for decision making became weaker in the presence of a poor value third option. The effect contrasts with another prominent potential mechanism during multi-alternative decision making – divisive normalization – the signatures of which were observed in the posterior parietal cortex. It has long been thought that the orbitofrontal cortex (OFC) and amygdala mediate reward-guided behavioural adaptation. However, this viewpoint has been recently challenged. I recorded whole brain activity in macaques using fMRI while they performed an object discrimination reversal task over multiple testing sessions. I identified a lateral OFC (lOFC) region in which activity predicted adaptive win-stay/lose-shift behaviour. In contrast, anterior cingulate cortex (ACC) activity predicted future exploratory decisions regardless of reward outcome. Amygdala and lOFC activity was more strongly coupled for adaptive choice shifting and decoupled for task irrelevant reward memory. Day-to-day fluctuations in signals and signal coupling were correlated with day-to-day fluctuations in performance. These data demonstrate OFC, ACC, and amygdala each make unique contributions to flexible behaviour and credit assignment.
22

The Source of the Positivity Bias in Older Adults' Emotional Memory

Tomaszczyk, Jennifer Christina January 2007 (has links)
According to socioemotional selectivity theory (SST), old age is associated with a greater emphasis on self-regulation of emotional states, a focus that fosters a bias in processing positively valenced material in older adults. There is disagreement, however, about whether the “positivity bias” suggested by SST influences performance on memory tasks. Some studies suggest that older adults remember more positive than negative information, or simply less negative information, relative to younger adults, whereas other studies report no such differences. This thesis examined (1) whether variations across studies in encoding instructions or in personal relevance of study materials could account for these inconsistencies, and (2) whether differences in attention at encoding to positive, negative, and neutral stimuli could account for the positivity bias in older adults’ later memory for the stimuli. In Experiment 1, younger and older adults were instructed either to passively view positive, negative, and neutral pictures or to actively categorize them by valence. On a subsequent incidental recall test, older adults recalled equal numbers of positive and negative pictures, whereas younger adults recalled negative pictures best. There was no effect of encoding instructions. Crucially, when pictures were grouped into high and low personal relevance according to participants’ ratings, a positivity bias emerged only for low relevance pictures. In Experiment 2, attention to pictures at encoding was directly manipulated through use of a divided attention paradigm. Although divided attention lowered recall in both age groups, attention did not interact with age and valence. Taken together, the results suggest that variability in the personal relevance of study pictures may be the factor underlying cross-study differences in whether a positivity bias is observed in older adults’ memory.
23

The Source of the Positivity Bias in Older Adults' Emotional Memory

Tomaszczyk, Jennifer Christina January 2007 (has links)
According to socioemotional selectivity theory (SST), old age is associated with a greater emphasis on self-regulation of emotional states, a focus that fosters a bias in processing positively valenced material in older adults. There is disagreement, however, about whether the “positivity bias” suggested by SST influences performance on memory tasks. Some studies suggest that older adults remember more positive than negative information, or simply less negative information, relative to younger adults, whereas other studies report no such differences. This thesis examined (1) whether variations across studies in encoding instructions or in personal relevance of study materials could account for these inconsistencies, and (2) whether differences in attention at encoding to positive, negative, and neutral stimuli could account for the positivity bias in older adults’ later memory for the stimuli. In Experiment 1, younger and older adults were instructed either to passively view positive, negative, and neutral pictures or to actively categorize them by valence. On a subsequent incidental recall test, older adults recalled equal numbers of positive and negative pictures, whereas younger adults recalled negative pictures best. There was no effect of encoding instructions. Crucially, when pictures were grouped into high and low personal relevance according to participants’ ratings, a positivity bias emerged only for low relevance pictures. In Experiment 2, attention to pictures at encoding was directly manipulated through use of a divided attention paradigm. Although divided attention lowered recall in both age groups, attention did not interact with age and valence. Taken together, the results suggest that variability in the personal relevance of study pictures may be the factor underlying cross-study differences in whether a positivity bias is observed in older adults’ memory.
24

Inducing Slips of Action: Creating a Window Into Attention Failures

Clark, Amanda Jane January 2007 (has links)
Many of our daily activities are achieved through goal-oriented routines which illustrates the adaptability and efficiency of information processing. Nevertheless, slips of action do occur. This study was designed to determine if slips of action can be induced in a well learned task and if so, how these slips affect specific indicators of task performance. Thirty (12 male) right-handed undergraduate participants were taught, with arrow cues, a sequence of dominant hand movements. Following this learning phase, a portion of the sequences were altered by either changing the spatial location of the arrow cue or by changing the actual movement goal. Results revealed that participants made numerous action slips which were most prevalent when the movement goal was altered. This suggests that participants were unable to disengage their expected movement plan and thus were vulnerable to errors. In addition to exploring the frequency of action slips we also looked at participants’ reaction and movement times on trials that preceded and followed errors and found that a speed-accuracy trade-off could not account for the slips. We also showed that frequency of slips on our task could reliably predict performance on the SART, a measure of inhibitory control, and the frequency of attention failures in daily living on the ARCES. Overall, the results of this study reveal that action slips can be induced by manipulating a well learned action routine and that the frequency of these induced slips reflects a participant’s tendency to commit action slips in everyday life.
25

Development of a measure of visuomotor control for assessing the long-term ef fects of concussion

Locklin, Jason January 2009 (has links)
Recently, researchers have found evidence that after a concussion, residual visuomotor control deficits may linger longer than working memory or psychomotor speed deficits. All of the major computer administered test batteries currently in use for concussion management rely on examination of the latter tasks, and lack any measure of visuomotor control. The present research set out to develop a task to measure visuomotor performance. Using a touch-screen computer, the task required participants to point towards or away from (i.e., antipointing) a target in a design simmilar to an anti-saccade task. The task required participants to use visual information to execute controlled movements, and is designed to measure movement planning, execution performance and accuracy. The task was delivered to a large sample of healthy individuals to develop a normative performance data set. A self-report questionnaire was used to identify a small group of individuals from the normative population who were identified with a prior history of concussion. These individuals were directly contrasted with the healthy individuals. While only a few reported moderate or severe concussions, and information about recency and number of occurrences was unavailable, performance differences were observed --providing evidence of residual deficits. In particular, while concussed individuals were not slower, or less accurate overall than the healthy population on the task, they demonstrated unusual hand and spatial asymmetries. Future research will compare recently concussed individuals with the normative set developed here, and will make direct comparisons with existing computer administered test batteries to determine the efficacy of visuomotor tasks for detecting the long-term effects of concussion.
26

Negotiating Varying Ground Terrain during Locomotion: Insights into the Role of Vision and the Effects of Aging

Marigold, Daniel January 2006 (has links)
We continually encounter different ground terrain such as slippery, compliant, uneven, rocky, and irregular terrain when walking, yet we know very little about how individuals safely negotiate this type of complex environment. Furthermore, we know little about how aging affects stability in these situations despite the increased risk of falls and fall-related injuries among older adults. Paramount to our comprehension of how individuals safely traverse challenging ground terrain is to understand how visual information is utilized as vision is the first line of defense for preparing for and/or avoiding potentially hazardous terrain or obstacles. Thus, the objective of this thesis was to provide a better understanding towards how individuals negotiate different ground terrain in the environment to maintain dynamic stability and prevent the occurrence of a fall. In particular, the role of vision and the effects of aging were investigated. Three studies focused on the role of vision while negotiating varying ground terrain while two studies examined stability across these surfaces. Two main conclusions can be drawn from the results of the three studies on the role of vision. First, regardless of age individuals fixate on highly task-relevant areas (i.e. surfaces eventually stepped on) in an on-line manner and by fixating approximately two steps ahead. Second, visual information from the lower visual field is important for negotiating varying ground terrain. This latter finding has implications for older adults who wear multi-focal glasses and suggests that these individuals should be cautious when wearing these glasses in complex environments. In terms of stability, the results suggest that young and older adults demonstrate greater instability when walking across varying unstable ground terrain compared to solid level ground. Older adults are particularly more unstable in the medial-lateral direction when negotiating the challenging terrain, which may explain the frequency of laterally directed falls and increased hip-fracture risk with advancing age. Interestingly, older adults appear more stable in the anterior-posterior direction; although, this can largely be explained by the cautious gait strategy (i.e. slower walking speed and shorter steps) adopted by these individuals. The results of the studies of my thesis provide valuable insight into how individuals safely negotiate different types of challenging ground terrain when walking. Importantly, this knowledge can serve as an initial step in attempting to reduce falling among those at risk.
27

Inducing Slips of Action: Creating a Window Into Attention Failures

Clark, Amanda Jane January 2007 (has links)
Many of our daily activities are achieved through goal-oriented routines which illustrates the adaptability and efficiency of information processing. Nevertheless, slips of action do occur. This study was designed to determine if slips of action can be induced in a well learned task and if so, how these slips affect specific indicators of task performance. Thirty (12 male) right-handed undergraduate participants were taught, with arrow cues, a sequence of dominant hand movements. Following this learning phase, a portion of the sequences were altered by either changing the spatial location of the arrow cue or by changing the actual movement goal. Results revealed that participants made numerous action slips which were most prevalent when the movement goal was altered. This suggests that participants were unable to disengage their expected movement plan and thus were vulnerable to errors. In addition to exploring the frequency of action slips we also looked at participants’ reaction and movement times on trials that preceded and followed errors and found that a speed-accuracy trade-off could not account for the slips. We also showed that frequency of slips on our task could reliably predict performance on the SART, a measure of inhibitory control, and the frequency of attention failures in daily living on the ARCES. Overall, the results of this study reveal that action slips can be induced by manipulating a well learned action routine and that the frequency of these induced slips reflects a participant’s tendency to commit action slips in everyday life.
28

Development of a measure of visuomotor control for assessing the long-term ef fects of concussion

Locklin, Jason January 2009 (has links)
Recently, researchers have found evidence that after a concussion, residual visuomotor control deficits may linger longer than working memory or psychomotor speed deficits. All of the major computer administered test batteries currently in use for concussion management rely on examination of the latter tasks, and lack any measure of visuomotor control. The present research set out to develop a task to measure visuomotor performance. Using a touch-screen computer, the task required participants to point towards or away from (i.e., antipointing) a target in a design simmilar to an anti-saccade task. The task required participants to use visual information to execute controlled movements, and is designed to measure movement planning, execution performance and accuracy. The task was delivered to a large sample of healthy individuals to develop a normative performance data set. A self-report questionnaire was used to identify a small group of individuals from the normative population who were identified with a prior history of concussion. These individuals were directly contrasted with the healthy individuals. While only a few reported moderate or severe concussions, and information about recency and number of occurrences was unavailable, performance differences were observed --providing evidence of residual deficits. In particular, while concussed individuals were not slower, or less accurate overall than the healthy population on the task, they demonstrated unusual hand and spatial asymmetries. Future research will compare recently concussed individuals with the normative set developed here, and will make direct comparisons with existing computer administered test batteries to determine the efficacy of visuomotor tasks for detecting the long-term effects of concussion.
29

Influence of area 5 on primary motor cortex: a paired-pulse TMS investigation in healthy adults

Ziluk, Angela 10 1900 (has links)
The neural correlates that underpin fine motor control of the hand and their connections with the primary motor cortex (M1) require further investigation. Brodmann’s area 5 located in the superior parietal lobule (SPL) is suggested to be an important cortical area involved in the processing of somatosensory input important for precision movements. Area 5 is present in monkey species capable of opposable thumb movements and it is proposed that this area evolved with the ability to execute manual behaviours such as pinch grip. Further, area 5 is dominated by the representation of the hand and forelimb, and has direct connectivity with M1 implicating its role in the control of hand movements. Few studies have investigated the function of area 5 in humans and none have examined the connectivity between area 5 and ipsilateral M1. This thesis presents a novel approach to study the influence of area 5 on M1 output in healthy and awake humans during the processing of somatosensory inputs and during performance of motor tasks involving the hand. Using paired pulse transcranial magnetic stimulation over left area 5 and ipsilateral M1, the connections between the two cortical loci was probed. It was hypothesized that area 5 would facilitate M1 output at short and long latencies during the processing of tactile inputs and during the performance of motor tasks compared to rest. The current results demonstrate that changes in M1 output are task and temporally specific. Facilitation of the motor evoked potential (MEP) was present at short latency of 6 ms during the processing of somatosensory input whereas inhibition was present during conditions where the hand was performing a task with the thumb and index finger. Further, an inhibitory effect was seen at 40 ms during cutaneous stimulation. In experiments 1 and 2, there was no net influence of area 5 on M1 output observed at rest. The findings presented may have revealed a novel path with which to alter the motor output, and possibly movement of hand muscles.
30

June Must be Right and 9 is on Top: An Investigation of Time-space and Number-form Synaesthesia

Jarick, Michelle Ann 09 December 2010 (has links)
Synaesthesia is a fascinating condition whereby individuals report extraordinary experiences when presented with ordinary stimuli. In this thesis, we examine an individual (L) who experiences time units (i.e., months and hours) and numbers as occupying specific spatial locations (e.g., January is 30º to the left). This type of spatial-form synaesthesia has been recently investigated by Smilek et al. (2007), demonstrating that synaesthetic time-space associations are highly consistent, occur regardless of intention, and can direct spatial attention. We extended this work in Chapter 2 by showing that for L, her time-space vantage point changed depending on whether the time units were seen or heard. For example, when L saw the word JANUARY, she reported experiencing January on her left side, however when she heard the word "January" she experienced the month on her right side. In this thesis, we validated L’s subjective reports using a spatial cueing task. The names of months were centrally presented followed by targets on the left or right. L was faster at detecting targets in validly cued locations relative to invalidly cued locations both for visually presented cues (January orients attention to the left) and for aurally presented cues (January orients attention to the right). We replicated these vantage-point dependent cueing effects also using hours of day. In Chapter 3, we further explored whether synaesthetic number forms could bias spatial attention using a spatial cueing and SNARC-type task. Two synaesthetes (L and B) both described experiencing the numbers 1 through 10 running vertically from bottom to top. Both experiments confirmed their synaesthetic number forms, such that when making odd-even judgments for the numbers 1, 2, 8, and 9, they showed SNARC-compatibility effects for up-down movements (aligned with their number form), but not left-right (misaligned) movements. Likewise in the spatial cueing task, both synaesthetes showed significantly faster response times to detect targets on the bottom of the display if preceded by a low number (1,2) and the top of the display if preceded by a high number (8,9), whereas they showed no cueing effects when targets appeared on the left or right (misaligned with their number forms). Both synaesthetes were, however, reliably faster to detect left targets following the presentation of numbers 10, and 11, and right targets following numbers 19 and 20 (running from left to right). Hence, we demonstrated that cueing and SNARC tasks could be used to empirically verify synaesthetic number forms. Moreover, we showed that numbers could direct spatial attention to idiosyncratic locations similar to time-units, replicating and extending our findings from Chapter 2. Lastly, Chapter 4 was aimed to explore the automaticity and involuntary nature of L’s number-forms. We continued to use the spatial cueing task and sought to eliminate any influence of strategy on L’s performance by: (1) shortening the interval between the cue and target onset to only 150 ms and (2) having the targets only fall in synaesthetically cued locations on 14.2% of trials. As a result, these manipulations should eliminate any cuing effects if L’s performance was attributable to intentionally using the cue to predict target location. However, our findings still showed an attentional bias consistent with L’s synaesthesia. We attributed L’s resilient cueing effects to the automaticity of her number-forms, thus demonstrating one of the hallmark attributes of synaesthesia. Overall, this series of studies convincingly demonstrated the reality of time-space and number-form synaesthesia and Chapter 5 concludes by discussing how this work has significantly contributed to the synaesthesia literature and to the study of perception overall.

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