Medicine is a field of science that is always changing and promoting new ideas and innovations. Throughout history, medicine has been an important factor in the lives of people around the world since the beginning of civilizations. This study focused on the literature of medicine as it relates to the Spanish Golden Age period. By looking at the history and critical studies in medicine during sixteenth and seventeenth century Spain as well as during the pre-colonial period in America, this thesis overviews the effects and influences in regards to health and illness in Spain and the Americas during the Spanish Golden Age era.