Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 24, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Thesis advisors: Dr. Keith W. Goyne and Dr. Robert N. Lerch. Includes bibliographical references.

Thesis (Ph. D.)--University of Pennsylvania, 1934. / "Reprint from the Journal of physical chemistry, vol. 39, no. 4, and no. 6, 1935." "References: " p. 13, 23.

Thesis (Ph. D.)--Johns Hopkins University, 1917. / Biography.

Thesis (Ph. D.)--University of Pennsylvania, 1934. / "Reprint from the Journal of physical chemistry, vol. 39, no. 4, and no. 6, 1935." "References: " p. 13, 23.

Yes / A comprehensive study of the thermal behavior of the 1:1 and 2:1 benzoic acid/isonicotinamide cocrystals is reported. The 1:1 material shows a simple unit cell expansion followed by melting upon heating. The 2:1 crystal exhibits more complex behavior. Its unit cell first expands upon heating, as a result of C–H···π interactions being lengthened. It then is converted into the 1:1 crystal, as demonstrated by significant changes in its X-ray diffraction pattern. The loss of 1 equiv of benzoic acid is confirmed by thermogravimetric analysis–mass spectrometry. Hot stage microscopy confirms that, as intuitively expected, the transformation begins at the crystal surface. The temperature at which conversion occurs is highly dependent on the sample mass and geometry, being reduced when the sample is under a gas flow or has a greater exposed surface area but increased when the heating rate is elevated.

No description available.

No description available.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1962. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 57-64).

Master of Science / Department of Animal Sciences and Industry / Jim Nelssen / A thorough literature review on feeding vitamin D₃ and 25(OH)D₃ revealed a large amount of research conducted in swine and poultry. In general, increasing vitamin D₃ concentrations or adding 25(OH)D₃ to the maternal diet increases the vitamin D₃ status of the dam and often the progeny as well. Varying results have been reported on the practical and valuable impacts of this elevated status with some topics including improved sow performance, changes in muscle fiber morphometrics, and growth performance to market. The first experiment used a total of 69 sows and the progeny from one group of 22 sows to determine the effects of feeding a combination of vitamin D₃ and 25(OH)D₃ to the sow. Differences in sow productivity and growth performance of progeny due to dietary treatment were not observed (P > 0.05). When pigs were sacrificed at birth, there were no treatment effects for all fiber morphometric measures (P > 0.170), except primary fiber number and the ratio of secondary to primary muscle fibers (P < 0.014). Pigs from the CON and DL fed sows had less primary fibers than pigs from sows fed the DH treatment (P < 0.046), but did not differ from each other (P = 0.732). These results suggest progeny went through a longer prenatal period of primary myogenesis which delayed the onset of secondary myogenesis. Pigs from DL fed sows had a smaller secondary to primary muscle fiber ratio compared to pigs from sows fed the CON treatment (P = 0.016), with pigs from sows fed DL treatment not differing from either (P > 0.057). There were treatment x time interactions for all sow and pig serum metabolites (P < 0.001). Therefore, we chose to compare treatment means within time period. At all time periods, sow serum 25(OH)D₃ concentrations differed for all treatments with the magnitude of difference largest at weaning (P < 0.011). The second and third experiment investigated the impact of adding benzoic acid and an essential oil blend to diets and creep feed. When these additives were included in growing pig diets in a 28-d trial, a main effect of time (P < 0.001) was detected where there was no evidence of difference during the first 3 weeks for ADG and G:F, however both responses decreased during the final week of the experiment (P < 0.001) and average pen BW increased (P < 0.001) for all time points. There was a treatment x time interaction (P = 0.003) for ADFI where during the first 3 weeks, there was no evidence of difference due to dietary treatment, but during the final week of the study, pigs consumed more (P = 0.007) of the control diet (2.38 kg/d control vs. 2.24 kg/d benzoic acid paired and essential oil blend). Fecal samples collected provided no evidence of differences (P > 0.05) in fecal pathogens due to dietary treatment. When these additives were included in the maternal diet and in the creep feed, they did not (P > 0.05) affect sow performance or preweaned piglet performance. Fecal swabbing of pigs the day before weaning showed they did not eat the creep feed and, therefore, no (P > 0.05) improvements in growth performance were observed in the nursery. In conclusion, adding benzoic acid and an essential oil blend to diets and creep feed did not affect growth performance and combining vitamin D₃ and 25(OH)D₃ in the maternal diet improved the vitamin D₃ status of the dam and progeny and increased primary muscle fibers at birth.

no / The formation of crystalline molecular complexes of benzoic acid and isonicotinamide with 1:1 and 2:1 compositions has been investigated through solution cocrystallization. The 1:1 complex was solely obtained from ethanol solutions, while either complex could be grown from aqueous and methanol solution by variation of the initial composition. The crystal structures of the 2:1 complex and a monohydrate of isonicotinamide were determined by single crystal X-ray diffraction. The intermolecular interactions in the crystal structure of the complex were compared with other published carboxylic acid:isonicotinamide molecular complexes, which highlights the robust nature of the acid · · · pyridine and acid · · · amide hydrogen bond, which exist in most cases. Complementary computational studies into the binding of pairs of these molecules by ab initio calculations were found to support the experimental observations and highlight the role of solvent in controlling the final crystalline form for multicomponent systems, through altering the hierarchy of intermolecular interactions.