In view of international digitalization and information trend, and to cope with the New 1-9 Curriculum education policy, the Taiwanese increasingly value information technology education development and methods. The researcher integrates Big6 information skills to school base curriculum with topic study process. A new teaching plan consisting two cycles is developed to test on a sample of 35 fourth graders. The researcher demonstrates the first cycle, and the students actively process the second cycle. The two-cycle teaching plan is to train students to utilize Big6 information skills in researches and promote students¡¦ capabilities of team work, demonstration, presentation, and critique. The researcher conducted and analyzed the data based on three sources consisting quantitative measuring tools, records, and reflections. Quantitative measuring tools include information technology usage investigation, information skill level self-check list, and deliberated comment tables. Records involve students¡¦ learning diaries, teacher¡¦s observant diaries and the teams¡¦ self-checked lists. Reflections engage teacher¡¦s and students¡¦ self reflections. The results of this research are as follows: 1. Big6 skills suit to harmoniously utilize in the two-cycle senior topic instruction program. 2. Applying Big6 skills in project-based learning promotes most students¡¦ learning in five areas including Big6 skills in research processes and study methods, topic-related information, research team work skills, information skills, and critically deliberating behavior. 3. Tested sample showed higher motivation in this process. 4. The researcher could acquire the growing expertise, which includes grasping the value of research, promoting the abilities of designing and compiling instruction program, enhancing the skill of applying and integrating the information technology, utilizing ¡§divided teams project-base¡¨ instruction model for research, and creating the students¡¦ accomplishment with accessing diversificately.