For the biotechnology industry in Taiwan, government gives fresh impetus to biotechnology industry, which makes it becoming a chief one in next stage. The biotechnology industry is also a priority event in ¡§The challenge to year 2008 nation development significant plan¡¨. IT is a matual industry in Taiwan. Thought the biotechnology is the star industry in next stage, but there is a question existed for all IT companies, how to invest in biotechnology? Bioinformatics seems to be the answer to the question. But is it the right answer? Are there any success storis in Taiwan? What did the do to success? Is there any other chance to invest in Taiwan? This study focuses on IT requirements of biotechnology industry. First, this study defines biotechnology, bioinformatics, and Bio-IT three industries. Second, finds out the IT supplychain between biotechnology companies, bioinformatics companies, and Bio-IT companies. The purpose of this study is not only to establish an IT supplychain model of biotechnology industry, but also raise a strategy to help IT companies successfully transfer from IT to biotechnology industry. This study proposes a ¡§Three stages investment strategy¡¨ to IT companies: First Stage: Diversification stragegy: Using the original IT technology and organization to provide Bio-IT service to biotechnology companies. In this stagegy, IT companies should take the software development project from biotechnology companies. Second Stage: Integration Stragegy: After gets the experiences and build the technology in developping Bio-related software, IT companies can integrate the technologies to develop bioinformatics software, and becomre a bioinformatics company. Third Stage: Alliance stragegy: The best way of bioinformatics companies is to stargegy alliance with pharmaceutical companies to develop drugs. In this stage, companies should also get the business from international. Key words: biotechnology, bioinformatics, Bio-IT, diversification, integration, alliance, strategy