The experimental material to be reported in this thesis represents the results of work carried out by the writer since the end of World War II. The studies arose out of three large surveys which were carried out under the direction of Dr. O.F. Denstedt of this department during the war. [...]

Chromatography is probably the most recent analytical technique to be adopted by laboratories in almost every part of the world. The extremely simple apparatus that is required, a covered container, a cylinder of filter paper and a simple spray, has made the technique of paper chromatography available to every laboratory. [...]

Although acetylcholine as a chemical substance was known as early as 1867 (14), it was not until the discovery of its powerful pharmacological effects by Hunt and Taveau (108), later extended by Dale (49) and others, that the compound attracted the attention of physiologists. [...]

The earliest observations that the adrenal medulla produces a substance which is added to the blood stream and has powerful effects on muscular tissue in general, expecially the heart and vascular system, were made by Oliver and Schafer in 1895, (1). [...]

Missing pages. / Aqueous suspensions of rat liver and brain can catalyze the enzymatic reduction of tetrazolium salts by monoamine oxidase preparations; this reaction requires a heat-stable, dialyzable factor(s) found in a variety of animal tissues and yeast.

Between 1882 and 1886, the Irish physician MacMunn focused attention on myohaematin or histohaematin, a pigment which he identified by spectroscopy in muscle and other tissue of various animal species. He noted the appearance of four bands in the visual spectrum upon simple chemical reduction and their disappearance after reoxidation. In muscle, he regarded this substance as separate and distinct from haemoglobin (myoglobin) and he concluded that it was involved in cellular respiration. Unfortunately, MacMunn's findings were severely criticized by some contemporaries and,therefore, remained forgotten until Keilin rediscovered and named it cytochrome, some forty years later. [...]

The ovary has been recognized as an endocrine organ for many years. This was established in many species, in classical fashion, by removing these organs and observing what occurred in the spayed animals (1). [...]

Missing pages. / Due in large measure to various medical advances and discoveries, modern man enjoys a prospect in longevity unknown to his forebears. This has led to an ever-increasing proportion of middle-aged and elderly individuals in our population. It is already apparent that this enlarging group of people is liable to certain diseases either unknown or at least less common in younger groups. [...]

The literature on the subject of clinical shock is voluminous and much of it is purely descriptive. For a survey of the more significant information, the reader is referred to numerous reviews (20, 21, 36, 61, 66, 73, 112, 113, 123, 200, 201, 262, 301, 311, 312, 317) including a recent one by the writer (181). [...]

The fertilized hen's egg at the beginning of incubation period consists of two main parts, the yolk and the egg-white or albumen. The yolk is the richer of the two in both nutrients and enzymes and consists of 35% fat, 15% protein, very little carbohydrate and about 50% water. [...]