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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Signals and noise in complex biological systems /

Rung, Johan, January 2007 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2007. / Härtill 5 uppsatser.

Integration of biological data /

Jakonienė, Vaida, January 2006 (has links)
Diss. Linköping : Linköpings universitet, 2006.

Chemogenomics : models of protein-ligand interaction space /

Strömbergsson, Helena, January 2009 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2009. / Härtill 5 uppsatser.

Algorithms for the calculation and visualisation of phylogenetic networks

Kloepper, Tobias Heinz, January 2008 (has links)
Tübingen, Univ., Diss., 2008.

Evolutionary bioinformatics predicting genetic stability of asexual genomes by global computing /

Loewe, Laurence. January 2003 (has links) (PDF)
München, Techn. Univ., Diss., 2002. / Computerdatei im Fernzugriff.

Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies

Martínez Barrio, Álvaro, January 2010 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2010.

From protein sequence to structural instability and disease

Wang, Lixiao, January 2010 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2010.

Evolutionary bioinformatics predicting genetic stability of asexual genomes by global computing /

Loewe, Laurence. January 2003 (has links) (PDF)
München, Techn. University, Diss., 2002.

Dynamics of Microbial Genome Evolution

Hooper, Sean January 2003 (has links)
<p>The success of microbial life on Earth can be attributed not only to environmental factors, but also to the surprising hardiness, adaptability and flexibility of the microbes themselves. They are able to quickly adapt to new niches or circumstances through gene evolution and also by sheer strength of numbers, where statistics favor otherwise rare events.</p><p>An integral part of adaptation is the plasticity of the genome; losing and acquiring genes depending on whether they are needed or not. Genomes can also be the birthplace of new gene functions, by duplicating and modifying existing genes. Genes can also be acquired from outside, transcending species boundaries. In this work, the focus is set primarily on duplication, deletion and import (lateral transfer) of genes – three factors contributing to the versatility and success of microbial life throughout the biosphere. </p><p>We have developed a compositional method of identifying genes that have been imported into a genome, and the rate of import/deletion turnover has been appreciated in a number of organisms. Furthermore, we propose a model of genome evolution by duplication, where through the principle of gene amplification, novel gene functions are discovered within genes with weak- or secondary protein functions. Subsequently, the novel function is maintained by selection and eventually optimized. Finally, we discuss a possible synergic link between lateral transfer and duplicative processes in gene innovation.</p>

Predicting Function of Genes and Proteins from Sequence, Structure and Expression Data

Hvidsten, Torgeir R. January 2004 (has links)
<p>Functional genomics refers to the task of determining gene and protein function for whole genomes, and requires computational analysis of large amounts of biological data including DNA and protein sequences, protein structures and gene expressions. Machine learning methods provide a powerful tool to this end by first inducing general models from such data and already characterized genes or proteins and then by providing hypotheses on the functions of the remaining, uncharacterized cases.</p><p>This study contains four parts giving novel contributions to functional genomics through the analysis of different biological data and different aspects of biological functions. Gene Ontology played an important part in this research providing a controlled vocabulary for describing the cellular roles of genes and proteins in terms of specific molecular functions and broad biological processes.</p><p>The first part used gene expression time profiles to learn models capable of predicting the participation of genes in biological processes. The model consists of IF-THEN rules associating biological processes with minimal set of discrete changes in expression level over limited periods of time. The models were used to hypothesize new biological processes for both characterized and uncharacterized genes.</p><p>The second part investigated the combinatorial nature of gene regulation by inducing IF-THEN rules associating minimal combinations of sequence motifs common to genes with similar expression profiles. Such combinations were shown to be significantly correlated to function, and provided hypotheses on the mechanisms behind the regulation of gene expression in several biological responses.</p><p>The third part used a novel concept of local descriptors of protein structure to investigate sequence patterns governing protein structure at a local level and to predict the topological class (fold) of protein domains from sequence. Finally, the fourth part used local descriptors to represent protein structure and induced IF-THEN rule models predicting molecular function from structure.</p>

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