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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Doc of bacteriophage P1 is an enzyme that inhibits translation and phosphorylates a protein target

Cale, Stephanie 31 December 2014 (has links)
<p> Doc induces cell death by inhibiting translation; however, the mechanism of Doc-induced cell death and the cellular target of the toxin were unknown. One theory suggested that Doc inhibits translation elongation by binding directly to the 30S ribosomal subunit. Later evidence showed catalytic activity in distant homologs of Doc. These homologs contain a Fic-domain that has been shown to modify target GTPases by AMPylation and phosphocholination. Therefore, [<sup>35</sup>S] &ndash; Met, &alpha;[<sup>32</sup>P] &ndash; ATP, and &gamma;[<sup>32</sup>P] &ndash; ATP were used in conjunction with an S30 extract to confirm that Doc inhibits translation, to assess the mechanism of modification, and to identify the modified target. The results showed that Doc is an enzyme that inhibits translation and phosphorylates a protein target.</p>
22

Study of MES function and the dynamic MES-4 pattern in Caenorhabditis elegans

Suh, Jinkyo. January 2007 (has links)
Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007. / Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2790. Adviser: Susan Strome. "Title from dissertation home page (viewed Jan. 24, 2008)."
23

Spatial and temporal phosphoregulation of MCAK during mitosis

Zhang, Xin. January 2007 (has links)
Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007. / Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2766. Adviser: Claire E. Walczak. "Title from dissertation home page (viewed Jan. 24, 2008)."
24

Target specificity and structural characterization of single-stranded DNA aptamer RT1t49, a broad inhibitor of HIV-1 reverse transcriptases

Kissel, Jay D. January 2007 (has links)
Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007. / Source: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4320. Adviser: Donald H. Burke-Aguero. Title from dissertation home page (viewed Apr. 22, 2008).
25

Genetic and biochemical analysis of a signal transduction pathway coordinating polar development and cell division in Caulobacter crescentus

Pierce, Deanne Lynn. January 2007 (has links)
Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007. / Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5726. Adviser: Yves V. Brun. Title from dissertation home page (viewed May 12, 2008).
26

Kinetic analysis of prion propagation and quantitative analysis of genetic interactions in yeast.

Collins, Sean Ryan. Unknown Date (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2006. / Source: Dissertation Abstracts International, Volume: 68-01, Section: B, page: 0085. Adviser: Jonathan S. Weissman.
27

Analysis of methylotrophic methanogenesis in Methanosarcina barkeri fusaro /

Welander, Paula Veronica. January 2007 (has links)
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. / Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7106. Adviser: William Metcalf. Includes bibliographical references. Available on microfilm from Pro Quest Information and Learning.
28

Genetic and biochemical analysis of the spliceosomal GTPase Snu114.

Brenner, Tamara J. Unknown Date (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2005. / Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6424. Adviser: Christine Guthrie.
29

Oxygen and food modulate Caenorhabditis elegans locomotory circuits.

Gray, Jesse M. Unknown Date (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2005. / Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6453. Adviser: Cornelia I. Bargmann.
30

Human immunodeficiency virus type I Tat-mediated gene regulation.

Jayakumar, Prerana. Unknown Date (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2006. / Source: Dissertation Abstracts International, Volume: 68-01, Section: B, page: 0091. Adviser: Eric Verdin.

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