Spelling suggestions: "subject:"angiology - genetics"" "subject:"angiology - kenetics""
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Functional characterization of OCTRL2 : an organic cation transporter expressed in the renal proximal tubulesReece, Mark T. January 1998 (has links)
No description available.
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Telomeric probes for fish : technical aspects and clinical applicationsBielanska, Magdalena M. January 1997 (has links)
No description available.
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TLE 1 expression correlates with mouse embryonic segmentation, Neurogenesis and epithelial determinationDehni, Ghassan. January 1996 (has links)
No description available.
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POSITIONAL CLONING OF THE DISORGANIZATION MUTATIONBrihn, Lesil E. January 2008 (has links)
No description available.
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Regulation of vein, an activating ligand of the drosophila EGF receptorWang, Shu-Huei 06 August 2003 (has links)
No description available.
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Genetic analysis of the yeast endo-exonuclease : implications of its involvement in DNA double-strand break repairAsefa, Benyam January 2001 (has links)
No description available.
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Genetic algorithms and cache replacement policyAltman, Erik Richter January 1991 (has links)
No description available.
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Study of the role of pax transcription factors and SP-related factors in C. Elegans organ developmentSleiman, Sama 07 January 2008 (has links)
No description available.
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Jun signaling during Drosophila developmentJud, Molly Christine 07 July 2016 (has links)
<p> Jun N-terminal kinase (JNK) signaling is a key modulator of development and disease in all multicellular organisms. One process in which the consequences of both gain and loss of JNK signaling can be monitored is embryonic dorsal closure (DC) in the fruit fly, <i>Drosophila melanogaster.</i> DC occurs midway through embryogenesis; it is the process by which the lateral epidermis expands bilaterally to meet and fuse at the dorsal midline, thereby encasing the entire embryo in epidermis. JNK signaling in leading edge (LE) cells (the dorsal-most row of epidermis) initiates closure. My studies of a novel but conserved JNK signaling antagonist, Raw, have provided several unique insights into: 1) Jun function as a component of the AP-1 transcription factor, and 2) the role of the epidermis as a signaling template mediating development of the epidermis and adjacent tissues.</p><p> My graduate work has built upon the demonstration that <i>raw</i> is required to prevent promiscuous JNK signaling in the embryonic epidermis just prior to DC. I have shown that <i>raw</i> is necessary for proper accumulation of Jun in LE cells required to define the LE, which functions as a signaling center required for epidermal closure as well as for underlying heart development. I have gone on to show that Jun accumulates at previously unrecognized sites in the embryonic epidermis, including tracheal pits and solitary epidermal cells lying directly above the peripheral nervous system (PNS). Jun activity is required for tracheal and nervous system defects observed in mutants of two JNK signaling antagonists, <i>raw</i> and <i> rib,</i> and indicates that cell signals within and to an adjacent tissue are integral to proper development. I have found that the epidermis plays an instructive role during development, and results from my work have led to insights into how JNK signaling centers in the epidermis coordinate morphological processes.</p><p> As Raw is a novel but conserved JNK signaling antagonist, I have built and tested models of its molecular mechanism of action as well. Bolstering conclusions of previous studies of mammalian c-Jun in cell culture, my data indicate that N-terminal phosphorylation is not an on/off switch, but rather it increases Jun stability for its activity as a component of the AP-1 transcription factor. <i>raw</i> mutants exhibit both high levels of Jun protein and an accumulation of phosphorylated Jun (P-Jun), and my data point to a role for Raw in effecting the Jun:P-Jun ratio via mediation of Jun degradation. In deciphering the mechanism of Raw function, we are gaining significant new insights into previously unrecognized mechanisms of JNK signaling regulation. Understanding these mechanisms will be important for dissecting the etiology of developmental abnormalities and diseases, such as cancer, which hinge on the Goldilocks effect, having just the right amount of signaling at just the right time.</p>
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Epicuticular wax in Arabidopsis thaliana: A study of the genetics, chemistry, structure, and interactions with insectsRashotte, Aaron Michael January 1999 (has links)
Epicuticular wax (EW) forms the outermost layer over aerial portions of a plant. EW has been studied in plants for more than 100 years, yet there is a great deal that is still not known about epicuticular wax. The work in this dissertation has taken a broad view in investigating EW of Arabidopsis thaliana. In this dissertation I examined EW chemistry, EW structure, and mapped positions of existing and novel eceriferum or cer mutants. Additionally, I worked to develop new EW pathway models, establish correlations between EW chemistry and structure, and examine a possible functional role for EW in insect interactions. More specifically this dissertation project has attempted to expand the baseline knowledge of EW and of EW mutants in A. thaliana.
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