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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

EXPRESSION OF MOUSE U1B GENES IN VIVO AND IN VITRO

Unknown Date (has links)
The expression of two mouse U1b-2 genes has been studied both in vivo, using DNA transfection experiments, and in vitro using isolated nuclei active in snRNA synthesis. The 5' flanking sequences of the two mouse U1b-2 genes were determined and regions conserved among mammalian U1 genes identified. The 5' flanking sequences of the U1b genes are very similar to a previously reported rat U1a gene suggesting a close evolutionary relationship between the two genes. A promoter element, located between positions -201 and -228, was identified by stable transformation of mouse L cells and CHO cells, which normally express U1b, with cloned U1b-2 genes containing different lengths of 5' flanking sequence. Additional flanking sequences are required for efficient expression of U1b-2 genes in mouse C127 fibroblasts, which normally do not express U1b RNAs. In addition, the changes in the expression of U1b-2 and U1a RNAs was measured in early mouse embryogenesis. / The efficient synthesis U1, U2, and U3 snRNAs was demonstrated in isolated mouse myeloma nuclei. Accurate initiation of U1 RNA was shown to occur in this system by using (beta)-thionucleotides in the transcription reaction. There was no transcription upstream of the U1b gene but two classes of transcripts with 3' extensions were observed. Transcripts with 3-5 base 3' extensions were released from nuclei and trimmed to the mature size in vitro. In contrast, the transcripts with 200-300 base extensions were retained in nuclei and not processed to the mature size, suggesting that 3' end formation is normally coincident with transcription. / Source: Dissertation Abstracts International, Volume: 48-03, Section: B, page: 0659. / Thesis (Ph.D.)--The Florida State University, 1987.
12

Prolactin in human breast cancer

Gould, David R. (David Ross) January 1992 (has links)
No description available.
13

Role of methyl CpG binding protein 2 in regulation of urokinase plasminogen activator espression and breast cancer metastasis

Shikimi, Keisuke. January 2006 (has links)
No description available.
14

A study of yeast stress responses and conserved eukaryotic homeostatic mechanisms

Waller, Daniel January 2011 (has links)
No description available.
15

Human origins of DNA replication : identification, analysis and application

Nielsen, Torsten January 1996 (has links)
No description available.
16

Phosphoregulation of CdGAP and DCC, proteins involved in actin dynamics

Tcherkezian, Joseph. January 2005 (has links)
No description available.
17

Distinct regulation of CDPCux : by cyclinCdk complexes

Santaguida, Marianne Theresa. January 2005 (has links)
No description available.
18

Protein subcellular localization : analysis and prediction using the endoplasmic reticulum as a model organelle.

Scott, Michelle. January 2005 (has links)
No description available.
19

Role of CFTR and MRP1 in determining intra-and extra- cellular glutathione in Calu-3 cells

Pavlovic, Cliff January 2009 (has links)
No description available.
20

Role BAP31 complex at the endoplasmic reticulum in normal cell physiology and apoptosis

Stojanovic, Marina. January 2006 (has links)
No description available.

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