Catastrophic event emergency planning has emerged as one of the most important operations management areas. Much of the successes of a response plan rely on the ability to maintain an operating transportation infrastructure. In recent years urban areas have become susceptible to biological terrorist attacks due to their size and demographics. To mitigate the devastating effects of an attack, a comprehensive catastrophic event response plan is devised. The characteristics of the disease (dormant periods, signs/symptoms), daily traffic operations and trip distributions, patient-choice hospital modeling and emergency center corridor optimization are all elements of an effective response plan. Simulation and optimization modeling of this plan becomes a faster-than-real-time tool in replicating urban area degradation. Therefore, allowing planners to identify "worst case scenarios" within the network and implement Dynamic Traffic Assignment (DTA) techniques and a non-linear departure time slot allocation mathematical model ensuring infected populations receive treatment and/or vaccinations efficiently. / by William C. Degnan. / Thesis (M.S.C.S.)--Florida Atlantic University, 2010. / Includes bibliography. / Mode of access: World Wide Web. / System requirements: Adobe Reader.