Improving the retention and graduation of African Americans and other minority groups in higher education is an important but highly politicized issue on college and university campuses. Prior studies emphasize the relationship between minority retention and achievement, cultural diversity, and racial policies and climates at predominantly White colleges and universities in the United States. In response to the need for further research, the effects of institutional actions related to diversity, minority group and African American retention, and social integration initiatives on African American graduation rates were examined for a national sample of United States (U.S.) colleges and universities. From a potential list of 7,018 colleges and universities, 2,233 met the inclusion criteria for the study. But necessary and complete information from national directories and the census could only be found for the final sample of 1,105. After dropping 30 outliers, several multiple regression analyses identified the institutional actions, social, and demographic factors that best predicted graduation rates. Public U.S. colleges and universities located in the Midwest region had lower African American graduation rates than private colleges and universities located in the South. Higher African American graduation rates occurred in colleges and universities with Black cultural centers, higher first-year retention rates, higher women enrollment rates, a higher number of student organizations, and Division III athletic programs. Colleges and universities located in a town had higher African American graduation rates than those located in a city, suburb, or rural area.