by Leung Kwok-sui. / Thesis (M.D.)--Chinese University of Hong Kong, 1991. / Bibliography: leaves 112-121. / ACKNOWLEDGEMENTS --- p.iii / ABSTRACT --- p.v / LIST OF FIGURES --- p.xi / LIST OF TABLES --- p.xvii / CHAPTER / Chapter I --- Introduction --- p.1 / Chapter II --- The Evolution of the Fixation Devices for Peritrochanteric Fractures --- p.13 / Chapter II.1 --- Patho-anatomy and Biomechanics of Peritrochanteric Fractures --- p.14 / Chapter II.2 --- A Review of the Implants Available for Peritrochanteric Fractures --- p.19 / Chapter III --- Methodology --- p.39 / Chapter III.1 --- Biomechanical Analysis of the Gamma Nail and the Dynamic Hip Screw --- p.40 / Chapter III. 1.1 --- The Testing Machine and Equipments --- p.40 / Chapter III. 1.2 --- The Design of the Testing Jig --- p.41 / Chapter III. 1.3 --- The Test of the Sliding Characteristics of the Gamma Lag Screw --- p.43 / Chapter III. 1.4 --- The Biomechanical Behaviour of Gamma Nail Fixation and the Dynamic Hip Screw Fixation in Cadaveric Femora --- p.47 / Chapter III.2 --- Randomized Prospective Trial of Gamma Nail and Dynamic Hip Screw in the Treatment of Peritrochanteric Fractures Among Geriatric Patients --- p.51 / Chapter III.3 --- Anthropometric Study of Chinese Femora with Respect to the Design of the Gamma Nail and the Application of the Anthropometric Data for the Modification of the Gamma Nail --- p.55 / Chapter III.4 --- Method of Statistical Analysis --- p.61 / Chapter IV --- Results --- p.62 / Chapter IV. 1 --- The Biomechanical Analysis of the Gamma Nail and the Dynamic Hip Screws --- p.63 / Chapter IV. 1.1 --- The Sliding Characteristics of Gamma Lag Screw --- p.63 / Chapter IV. 1.2 --- The Biomechanical Behaviours of Gamma Nail and the Dynamic Hip Screw --- p.65 / Chapter IV.2 --- Clinical Studies --- p.70 / Chapter IV.2.1 --- Randomised Prospective Trial of Gamma Nail and Dynamic Hip Screw in the Treatment of Peritrochanteric Fractures --- p.70 / Chapter IV.2.2 --- Comparisons between the Clinical Use of Standard and Modified Gamma Nails --- p.75 / Chapter IV.3 --- The Anthropometric Study of the Proximal Chinese Femora and the Application of Anthropometric Data on the Modification of Gamma Nails --- p.78 / Chapter V --- Discussion --- p.85 / Chapter VI --- Conclusion --- p.109 / REFERENCES --- p.112 / APPENDICES --- p.122 / Chapter Appendix 1 --- Data Record Sheet of Retrospective Analysis of Geriatric Fractures Treated in the Prince of Wales Hospital --- p.123 / Chapter Appendix 2 --- Calibration Curve of the Linear Variable Differential Transformer (LVDT) --- p.125 / Chapter Appendix 3 --- Data Record Sheets for the Randomized Prospective Trial of Gamma Nail and Dynamic Hip Screw --- p.126 / Chapter Appendix 4 --- Operative Procedure of Dynamic Hip Screw and Gamma Nail - A Summary and Modifications --- p.132 / Chapter Appendix 5 --- Methodology for the Measurement of the Sliding of the Lag Screw of Gamma Nail on Serial X-ray Films --- p.138 / Chapter Appendix 6 --- Results of X-ray Measurement and Bone Densitometry Measurement of Cadaveric Femora --- p.142 / Chapter Appendix 7 --- Extra Data from the Results of the Randomized Prospective Trial of Gamma Nail and Dynamic Hip Screw --- p.144 / Chapter Appendix 8 --- Results of Anthropometric Study of 30 Chinese Femora --- p.145

In a 6-week rat model it was demonstrated that a small dose of peri-implant zoledronic acid (ZA) increased local bone formation 3-fold compared with controls. Ancillary in vitro studies using 14C-labeled ZA implant doses demonstrated biphasic elution profiles for implants coated with hydroxyapatite; complete ZA release occurred within one to three weeks in serum compared with only 60% ZA release after 12 weeks in water. Implants without hydroxyapatite coating showed more burst-type release profiles and full ZA elution within 24 hours of hydration in serum or water. Canine studies at 6 weeks using implants with 14C-labeled ZA showed that the compound remained localized, with the greatest ZA concentration immediately adjacent to the implant. Although there was evidence of skeletal ZA distribution via diffusion into the circulation, the levels were two orders of magnitude less than at the implant site.

No description available.

O efeito da terapia por ondas de choque (TOC) na consolidação óssea, após osteotomias bilaterais dos fêmures e osteossínteses com hastes bloqueadas, foi estudado em 8 cães. Os fêmures direitos constituíram o grupo controle e os esquerdos, o grupo tratado, que recebeu 2000 pulsos de ondas de choque de 18 kV, energia de 5mJ (-6dB), na linha da fratura. Radiografias após 4, 8 e 12 semanas, revelaram maior proliferação periosteal no grupo tratado. Os resultados dos exames cintilográficos (razão tratado/controle), realizados na 2a, 4a, 6a, 8a, 10a e 12a semanas, foram estatisticamente superiores no grupo tratado. A TOC provocou aumento da atividade osteogênica na consolidação de fraturas agudas / The effect of extracorporeal shock wave therapy (ESWT) on bone healing, after bilateral femoral osteotomies and osteosynthesis with interlocking nails, was studied in 8 dogs. The right femurs composed the control group, and the left femurs, the treated group, which received 2000 pulses of shock wave, with 18 kV, 5 mJ (-6dB) energy on the fracture line. Radiographs after 4, 8 and 12 weeks, revealed increased periosteal proliferation in the treated group. The results (treated/control ratio) of the scintigraphic exams, performed on weeks 2, 4, 6, 8, 10 and 12, were statistically higher for the treated group. The ESWT led to increased osteogenic activity on acute fracture's bone healing.

O efeito da terapia por ondas de choque (TOC) na consolidação óssea, após osteotomias bilaterais dos fêmures e osteossínteses com hastes bloqueadas, foi estudado em 8 cães. Os fêmures direitos constituíram o grupo controle e os esquerdos, o grupo tratado, que recebeu 2000 pulsos de ondas de choque de 18 kV, energia de 5mJ (-6dB), na linha da fratura. Radiografias após 4, 8 e 12 semanas, revelaram maior proliferação periosteal no grupo tratado. Os resultados dos exames cintilográficos (razão tratado/controle), realizados na 2a, 4a, 6a, 8a, 10a e 12a semanas, foram estatisticamente superiores no grupo tratado. A TOC provocou aumento da atividade osteogênica na consolidação de fraturas agudas / The effect of extracorporeal shock wave therapy (ESWT) on bone healing, after bilateral femoral osteotomies and osteosynthesis with interlocking nails, was studied in 8 dogs. The right femurs composed the control group, and the left femurs, the treated group, which received 2000 pulses of shock wave, with 18 kV, 5 mJ (-6dB) energy on the fracture line. Radiographs after 4, 8 and 12 weeks, revealed increased periosteal proliferation in the treated group. The results (treated/control ratio) of the scintigraphic exams, performed on weeks 2, 4, 6, 8, 10 and 12, were statistically higher for the treated group. The ESWT led to increased osteogenic activity on acute fracture's bone healing.