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Dietary boron deficiency and elevated in vitro boron concentrations reduce survival of the murine gastrointestinal nematode, Heligmosomoides bakeriBourgeois, Annie-Claude. January 2006 (has links)
No description available.
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Dietary boron deficiency and elevated in vitro boron concentrations reduce survival of the murine gastrointestinal nematode, Heligmosomoides bakeriBourgeois, Annie-Claude. January 2006 (has links)
In the past 20 years, boron has been identified as an essential trace element for animals and humans but also as an increasingly important industrial pollutant. We examined first whether boron influenced survival of the gastrointestinal nematode Heligmosomoides bakeri. Female Balb/c mice were fed deficient (0.1 mug B/g), marginal (2.0 mug B/g) or control (12.0 mug B/g) diets, and infected with third-stage larvae. Although liver boron concentrations did not differ among diet groups, dietary boron deficiency impaired survival of the parasite and modulated a broad range of cytokines and chemokines. On the other hand, infection history altered liver mineral concentrations. Second, we examined whether elevated boron concentrations would exert toxic effects on H. bakeri in vitro. Boron toxicity was evidenced by reduced motility, fecundity, infectivity and survival. Feeding stages and free-living stages were more sensitive than non-feeding stages and parasitic stages respectively in a dose-dependent manner.
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