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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy and synthesis of 2,3-dideoxy-2,3-methanoribofuranoside glycosyl donors and a study of their use in stereocontrolled glycosylation reactions

Basak, Prakitri, January 2003 (has links)
Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xiii, 279 p.: ill. (some col.). Includes abstract and vita. Advisor: Todd L. Lowary, Dept. of Chemistry. Includes bibliographical references (p. 150-154).
2

Design and implementation of a boron neutron capture therapy research facility and dosimetry program

Martsolf, Steven W. 21 May 1993 (has links)
Graduation date: 1994
3

Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy and Synthesis of 2,3-dideoxy-2,3-methanoribofuranoside glycosyl donors and a study of their use in stereocontrolled glycosylation reactions

Basak, Prakriti. January 2003 (has links)
Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xiii, 279 p.: ill. (some col.). Includes abstract and vita. Advisor: Todd L. Lowary, Dept. of Chemistry. Includes bibliographical references (p. 150-154).
4

Epithermal neutron beam design at the Oregon State University TRIGA Mark II reactor (OSTR) based on Monte Carlo methods

Tiyapun, Kanokrat 12 March 1997 (has links)
Graduation date: 1997
5

Thymidine kinase as a molecular target for the development of novel anticancer and antibiotic agents

Byun, Youngjoo, January 2006 (has links)
Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 201-231).
6

The synthetic and bioinorganic chemistry of carboranes /

Schaffer, Paul. Valliant, John Fitzmaurice. January 1900 (has links)
Thesis (Ph.D.)--McMaster University, 2003. / Advisor: John Fitzmaurice Valliant. Accompanying CD-ROM contains the text, plus additional material (appendices I and II). Includes bibliographical references. Also available via World Wide Web.
7

The use of ������Co cell survival curves in BNCT research

Johnson, Jennifer Elizabeth 08 June 1994 (has links)
The cell survival curve is the only means by which to both qualitatively and quantitatively assess morphologic alterations directly resulting from in vitro irradiation of the cell. A ������Co cell survival curve experiment has successfully demonstrated the response of the AtT-20 clone mammalian cell line to the effects of gamma rays. With the results of this experiment, a low LET radiation cell survival curve now exists to be used as a comparative upon the completion of BNCT cell survival curves. / Graduation date: 1995
8

STRUCTURAL ANALYSIS AND SYNTHETIC PROGRESS TOWARDS SMALL MOLECULES AS MODULATORS OF ANGIOGENESIS AT THE CELLULAR AND TRANSCRIPTIONAL LEVELS

Polaske, Nathan Walter January 2008 (has links)
Progress towards the design and the application of small molecules as inhibitors of angiogenesis is reported. First, the regulation of hypoxia inducible transcription with epipolythiodioxopiperazine (ETP) natural products is discussed, beginning with the exploration of the physical and chemical properties of ETP skeletal analogs, xylylene-linked bis-diketopiperazines (1,4-piperazine-2,5-diones, DKPs).The design, synthesis and solid-state structures of a new class of xylylene-linked bis(1,4-piperazine-2,5-diones) are reported in an effort to extend the molecular framework of piperazine-2,5-diones. These compounds were derived from piperazine-2,5-dione as the core structure, synthesized via a new efficient route, and their crystal structures were determined. We examined the effects of side chain substitution on conformations of the linked bis-DKPs in the solid state. The results suggested that the interplay between the attractive intermolecular interactions and repulsive steric interactions of the substituents at the C6 and C6' positions of the diketopiperazine rings is important in determining the solid-state conformations of xylylene-linked bis(piperazine-2,5-diones).Asymmetric alpha-sulfenylation reactions were designed and performed as a potential route to the synthesis of epipolythiodioxopiperazine natural products. First, a chiral auxiliary approach is reported, sulfenylating chiral azomethines of alpha-amino acids as epipolythiodiketopiperazine precursors in yields of 55% with de as high as 74%. Asymmetric organocatalytic alpha-sulfenylation of substituted piperazine-2,5-diones is also reported, with chiral cinchona alkaloids as bases and benzyl-substituted electrophilic sulfur transfer reagents. The reaction was investigated with varied catalyst loading, type of sulfenylating agent, temperature and solvent. The effects of ring substitution and type of catalyst on yield and enantioselectivity of the reaction are reported. The synthetic utility of the asymmetric alpha-sulfenylation in context of the synthesis of epipolythiodioxopiperazine fungal metabolites is discussed.Finally, chemical approach towards the inhibition of angiogenesis by targeting alpha v beta 3 integrin antagonists with synthetic multifunctional boron neutron capture therapy (BNCT) integrin ligands is presented. The novel synthesis of an alpha v beta 3 integrin antagonist containing a free amine group for peripheral modification is reported, along with the preparation of a bifunctional BNCT integrin ligand and a trifunctional BNCT integrin ligand containing a fluorescent dye. Synthetic challenges and potential therapeutic applications of these ligands are discussed.
9

An accelerator-based epithermal photoneutron source for boron neutron capture therapy

Mitchell, Hannah Elizabeth 05 1900 (has links)
No description available.
10

Neutron spectrum measurement for Boron Neutron Capture Therapy

Hefne, Jameel 08 1900 (has links)
No description available.

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