Thesis (MPH.) -- University of Limpopo, 2022 / Background: Acquired Immunodeficiency Syndrome still remains the leading cause of death globally. Understanding students’ views about the risk of Human Immunodeficiency Virus infection by exploring and describing their perceptions may help to design effective Human Immunodeficiency Virus prevention interventions. The tertiary institution environment offers a great opportunity for Human Immunodeficiency Virus high risk behaviours, including alcohol and drug abuse, unsafe sex, multiple sexual relationships, intergenerational and transactional sex. Despite the decline in the overall incidence of Human Immunodeficiency Virus infection, still a significant proportion of the youth population are at risk of Human Immunodeficiency Virus infection. Objectives: The study was to explore and describe perception of risk of Human Immunodeficiency Virus among students at the Institute of Development Management, Gaborone, Botswana Campus. Methodology: A qualitative, exploratory, descriptive study using semi-structured interviews with purposively selected second year Public Health students was conducted. Interviews were conducted using an interview guide. It was audio recorded until data saturation was reached, where eight students participated in the study. Voice recordings were transcribed verbatim and analysed thematically. Results: The findings reveals that some participants perceive themselves to be at risk of contracting Human Immunodeficiency Virus, while others perceive themselves as being not at risk of Human Immunodeficiency Virus infection. Several risk factors associated with Human Immunodeficiency Virus infection, for example, alcohol and drug abuse, multiple concurrent sexual relationships, intergenerational and transactional sex are revealed as challenges. They also expressed their fears in relation to Human Immunodefiency Virus testing, pregnancy and disclosure of Human Immunodeficiency Virus positive status due to the stigma and discrimination. Conclusion: High risk behaviours leading to Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome prevalence are still common among young people, hence the need for government and all stakeholders to specifically address them by coming up with specific behavioural intervention programmes.