Thesis (M Arch)--Montana State University--Bozeman, 2009. / Typescript. Chairperson, Graduate Committee: Thomas Wood. Includes bibliographical references (leaves 108-116).

What are the potentials and limitations of constructing a regional building culture in and around Bozeman, Montana? Starting with the theories of architectural regionalism, this thesis takes a pragmatic approach to synthesizing several topics—history, geography, technology, economy—and situating them within Bozeman’s specific context in order to assess the implications of constructing a regional building culture. This potential shift is viewed primarily as technological, but with the understanding that technology is not just objects but also a set of practices and knowledge embedded in the co-evolving structures of society. The main outcome of the research is therefore recommended points of action for builders, designers, and policymakers that would encourage the development of regional building practices, which are shown to have technological and economic benefits when compared with universal technologies. Limitations are discussed in terms of barriers to realizing these benefits, as well as possible problems and contradictions. To start, the various discourses of architectural regionalism are summarized to provide a theoretical footing. Next comes an overview of the history of Bozeman’s building culture, with an emphasis on how universal technologies and their related cultural assumptions have obscured the potential for regional building practices. This leads to the question of defining the region, which is taken up first in an analytical way, then more concretely by using geographic information systems (GIS) to map the region’s climate. Analysis of climatic variables suggests technological practices that could reduce consumption of fossil-fuel energy. These are discussed conjointly with a critique of regional materials and an assessment of how these regionally appropriate alternatives might emerge within conventional technological systems. The economic implications of regional technologies are discussed in terms of benefits and draw-backs. Finally, all these findings are put within the context of information gathered through interviews, which leads to concluding recommendations for action and critical reflections. / text

Thesis (M Architecture)--Montana State University--Bozeman, 2009. / Typescript. Chairperson, Graduate Committee: Maire O'Neill. Includes bibliographical references (leaves 54-60).

Thesis (D. Min.)--McCormick Theological Seminary, 1999. / Includes bibliographical references.

Thesis (M. Nursing)--Montana State University--Bozeman, 2006. / Typescript. Chairperson, Graduate Committee: Patricia Holkup. Includes bibliographical references (leaves 118-125).

Prepared for The National Park Service, United States Department of Interior, Yellowstone, Wyoming / The goal of this investigation has been the reconstruction of past seasonal climate for the period 1750-1910 (161 years) in the Yellowstone National Park region based upon tree-ring data. Tree-ring series are useful in the reconstruction of past climate owing to the availability of large numbers of trees, the great longevity of trees, and the critical fact that the climatic information they contain is accumulated over specific years. In this project a number of tree-ring series from the region around Yellowstone National Park have been calibrated against short-term (1912-1971) seasonal temperature and precipitation data for Bozeman, Moran, Red Lodge, and Yellowstone Park. From these calibrations, long-term seasonal temperature and precipitation records have been reconstructed for each of the four stations. A major reason for these reconstructions has been the need for long-term climatic data that can be used to indicate potential variations in the climate of the park region. Knowledge of these climatic variations may facilitate estimates of natural food supplies or availability of forage in winter as related to snow depth. Previously such estimates have had to be based upon relatively short-term climatic data which undoubtedly do not encompass all possible climatic variations. With this in mind, a series of precipitation and temperature maps have been produced to indicate some of the seasonal extremes that have probably been experienced since 1750 within a given year or group of years as indicated by the tree -ring data. It is hoped that these maps will be useful to various types of researchers involved in planning within Yellowstone National Park.

Thesis (Ed. D.)--Montana State University--Bozeman, 2005. / Title from PDF t.p. (viewed on June 10, 2006). Chairperson, Graduate Committee: Larry Baker. Includes bibliographical references (p. 219-224).

abstract: The bleomycins are a family of glycopeptide-derived antibiotics isolated from various Streptomyces species and have been the subject of much attention from the scientific community as a consequence of their antitumor activity. Bleomycin clinically and is an integral part of a number of combination chemotherapy regimens. It has previously been shown that bleomycin has the ability to selectively target tumor cells over their non-malignant counterparts. Pyrimidoblamic acid, the N-terminal metal ion binding domain of bleomycin is known to be the moiety that is responsible for O2 activation and the subsequent chemistry leading to DNA strand scission and overall antitumor activity. Chapter 1 describes bleomycin and related DNA targeting antitumor agents as well as the specific structural domains of bleomycin. Various structural analogues of pyrimidoblamic acid were synthesized and subsequently incorporated into their corresponding full deglycoBLM A6 derivatives by utilizing a solid support. Their activity was measured using a pSP64 DNA plasmid relaxation assay and is summarized in Chapter 2. The specifics of bleomycin—DNA interaction and kinetics were studied via surface plasmon resonance and are presented in Chapter 3. By utilizing carefully selected 64-nucleotide DNA hairpins with variable 16-mer regions whose sequences showed strong binding in past selection studies, a kinetic profile was obtained for several BLMs for the first time since bleomycin was discovered in 1966. The disaccharide moiety of bleomycin has been previously shown to be a specific tumor cell targeting element comprised of L-gulose-D-mannose, especially between MCF-7 (breast cancer cells) and MCF-10A ("normal" breast cells). This phenomenon was further investigated via fluorescence microscopy using multiple cancerous cell lines with matched "normal" counterparts and is fully described in Chapter 4. / Dissertation/Thesis / Ph.D. Chemistry 2013

Thesis (Ph. D.)--University of Wisconsin, 1959. / Extension Repository Collection. Typescript (carbon copy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves [175]-177).