The aim of this thesis was to investigate the well-being of patients in clinical neuroscience settings. Both the systematic review and research paper are being prepared for submission to the journal of Neuropsychological Rehabilitation, the guidelines of which are included in the appendices (Appendix 1).Paper one is a systematic review of the literature investigating the prevalence of depression following traumatic brain injury (TBI). 26 papers were reviewed with 15 meeting quality assessment criteria and were described in further detail. The prevalence of depression following TBI, reported in the reviewed studies, varied between 19% and 46%.The quality of the methodology of the studies is evaluated and discussed.The research paper (paper two) investigated the relationship between well-being, cognitive impairment and dependency using care mapping - neurorehabilitation (DCM-NR) as a measure of well-being. This study applied DCM-NR in a range of clinical neuroscience settings. Participants considered to have severe cognitive impairment were found to have significantly lower well-being (as measured by DCM-NR), and to be more dependent than participants with moderate, mild or no cognitive impairment. Overall level of dependency and cognitive impairment accounted for 23.9% of the variance in well-being scores from the DCM-NR.Paper three is a critical appraisal of the systematic review and research paper. Pertinent issues, including methodological limitations, relevant to the two papers are discussed in addition to clinical and research considerations.