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The effects of branched-chain amino acid supplementation on the exercise time to exhaustion in sedentary individualsCowman, Jason. Haymes, Emily M., January 2003 (has links)
Thesis (M.S.)--Florida State University, 2003. / Advisor: Dr. Emily Haymes, Florida State University, College of Human Sciences, Dept. of Nutrition, Food, and Exercise Science. Title and description from dissertation home page (viewed Feb. 26, 2004). Includes bibliographical references.
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Isolation of human BCAD gene and analysis of putative BCAD deficiencyFu, Katherine January 1993 (has links)
The 2-methylbranched chain acyl-CoA dehydrogenase (BCAD) is a mitochondrial enzyme that catalyzes the third reaction in isoleucine and valine metabolism, the oxidation of 2-methylbutyryl-CoA and isobutyryl-CoA, respectively. BCAD deficiency would result in the accumulation of branched chain acyl-CoAs or their derivatives. Three patients with a putative defect in BCAD have been reported. This study consists of a molecular examination of one such patient as well as the characterization of the BCAD gene. In Northern blot analysis of human fibroblast RNA, the BCAD cDNA hybridized to two RNA species of 2.7 and 6.5 kb. The 2.7 kb band corresponds to the size of the BCAD cDNA, which consists of the entire coding region of 1.3 kb and a 3$ sp prime$ untranslated region of 1.4 kb. The coding regions of the BCAD gene span approximately 21 kb and consist of 12 exons and 11 introns. The exons range in size from 39 to 108 bp. In the analysis of the putative BCAD-deficient patient, no significant difference was observed at the level of DNA (Southern), RNA (Northern) or protein (Western) when compared to controls, suggesting that the BCAD gene in this patient did not contain any large insertions or deletions, or a frameshift mutation. The single strand conformation polymorphism (SSCP) technique and sequencing of the entire coding region did not reveal any disease-causing mutations but two polymorphisms were identified: one in exon 6 and the other in exon 10.
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Nutritional status of hospitalized geriatrics and the effects of branched-chain amino acids supplementation on pressure sore healing /Tang, Kwan-yi, Emily. January 2000 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 136-166).
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Isolation of human BCAD gene and analysis of putative BCAD deficiencyFu, Katherine January 1993 (has links)
No description available.
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The Influence of Chronic Branched-Chain Amino Acid Supplementation on Measures of Central and Peripheral Fatigue in Training AthletesWhiton, Tara K. 01 August 2019 (has links)
Branched-chain amino acid (BCAA) supplementation may improve recovery from competitive endurance training by reducing symptoms of central and peripheral fatigue. The purpose of this dissertation was to provide evidence for the use of BCAAs as a training nutrition strategy in order to improve recovery from training and further drive adaptive processes to training by increasing readiness to train. Collegiate distance runners undergoing intense competitive endurance training were monitored for symptoms of muscular soreness and psychological stress through a rated soreness chart and the Daily Analysis of Life Demands for Athletes Survey (DALDA) while taking either a BCAA supplement or a placebo. When on the BCAA supplement, athletes reported significantly fewer symptoms of psychological stress and reduced muscular soreness. These results point to the importance of nutrient bioavailability, specifically BCAAs, on recovery parameters when undergoing intensive training. This concept was also demonstrated in a case study on a trained distance runner who underwent intensive training for an ultra-endurance marathon. Running kinematics were assessed using Kinovea open-sourced software (Version 0.8.15) during a series of constant-paced endurance runs while on the BCAA supplement or a placebo. We observed a reduction in vertical oscillation when the runner was on the BCAA supplement, indicating improved muscle recovery and therefore efficiency of movement. Improving recovery by reducing global central and peripheral fatigue symptoms may increase readiness to train and further promote desired training adaptations.
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Expression studies on the shortbranched chain acyl-CoA dehydrogenase (SBCAD) geneVicanek, Caroline Michaela January 1995 (has links)
Short/branched chain acyl-CoA dehydrogenase (SBCAD), a member of the acyl-CoA dehydrogenase (ACD) family of enzymes, catalyzes the oxidation of branched chain fatty acids and the branched chain amino acids isoleucine and valine. This research project focuses on expression studies of the SBCAD gene. Northern blot analysis detected two SBCAD mRNA species of 2.7 and 6.5 kb in various human tissues and cell types. A single 4.1 and 2.0 kb SBCAD message was detected in rat and pig tissues, respectively, revealing a species difference in SBCAD mRNA size. Studies of human and rat SBCAD tissue-specificity and relative abundance, at both the RNA and protein levels, identified liver and kidney as the tissues with the highest levels of SBCAD expression, establishing a unique tissue-specific expression pattern that is not seen among the other members of the ACD family. Furthermore, a fetal and adult difference in SBCAD expression was observed in human kidney, suggesting that the SBCAD gene may be developmentally regulated in some tissues. Finally, an attempt was made to isolate and characterize the SBCAD promoter region in order to provide valuable data for future SBCAD promoter studies.
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The effects of branched-chain amino acid and leucine ingestion on the ERK1/2 MAP kinase signal transduction pathway in conjunction with an acute bout of heavy resistance exerciseCampbell, Bill. Willoughby, Darryn Scott, January 2007 (has links)
Thesis (Ph.D.)--Baylor University, 2007. / Includes bibliographical references (p. 134-146).
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The effects of heavy resistance exercise in combination with orally administered branched-chain amino acids or leucine on insulin signaling and Akt/mTOR pathway activity in active malesLa Bounty, Paul. Willoughby, Darryn Scott, January 2007 (has links)
Thesis (Ph.D.)--Baylor University, 2007. / Includes bibliographical references (p. 145-152).
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The effects of branched-chain amino acid supplementation on indirect indicators of muscle damage and performanceGreer, Beau Kjerulf. Haymes, Emily M., January 2006 (has links)
Thesis (Ph. D.)--Florida State University, 2006. / Advisor: Emily Haymes, Florida State University, College of Human Sciences, Dept. of Food, Nutrition, and Exercise Sciences. Title and description from dissertation home page (viewed Sept. 19, 2006). Document formatted into pages; contains xi, 123 pages. Includes bibliographical references.
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Crystal structure determination and site-directed mutagenesis of active site residues in Escherichia coli ketol-acid reductoisomerase /Tyagi, Rajiv. January 2005 (has links) (PDF)
Thesis (Ph.D.) - University of Queensland, 2005. / Includes bibliography.
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