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Role of Jak/Stat pathway in the pathogenesis of breast cancerZhang, Qifang. January 1900 (has links)
Thesis (Ph.D.)--Virginia Commonwealth University, 2010. / Prepared for: Dept. of Biochemistry. Title from resource description page. Includes bibliographical references.
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In vitro modeling of breast cancer /Rao, Krishna, January 2002 (has links)
Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 165-186).
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Risk factors for ipsilateral breast tumor recurrence and uncontrolled local disease /Dalberg, Kristina, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.
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A study of women's knowledge, habits and methods of breast self-examinationDe Muth, Judith Severson. January 1974 (has links)
Thesis (M.S.)--University of Wisconsin--Madison, School of Nursing, 1974. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 57-60)
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The BRCA1 gene in Chinese women. / CUHK electronic theses & dissertations collection / Digital dissertation consortiumJanuary 1999 (has links)
by Choy Kwong Wai. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (p. 120-138). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.
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Understanding the role of cofactor of breast cancer susceptinility gene 1 (COBRA1) in transcriptional regulation /Blair, Ashley Lauren. January 2007 (has links)
Thesis (Ph. D.)--University of Virginia, 2007. / Includes bibliographical references. Also available online through Digital Dissertations.
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Soluble c-erbB-2 fragment in serum correlates with disease stage and predicts for shortened survival in patients with early stage and advanced breast cancer.Kandl, H. January 1994 (has links)
A research report submitted to the Faculty of Medicine university of tho
Witwatersrand, Johannesburg, in partial fulfilment of the requirements
for the Degree of Master of science in Medicine. / Breast cancer is a major health problem, afflicting up to 1 in 9 women in developed countries
with Western diet and life style. While screening programs have led to earlier diagnosis,
including diagnosis at a pre-invasive stage in a number of women, the majority of patients with
breast cancer still present with clinically detectable, invasive breast cancer, which even if
clinically localised still carries the risk of systemic micrometastases, Such patients have been
shown to benefit both in terms of disease free as well as of overall survival from the addition
of adjuvant systemic treatment.
The identification of progostic factors which can be used to tailor specific forms of adjuvant
treatment to the patient's disease has been an important goal of breast cancer research during
the last 20 years. A particularly important goal is the early identification of poor risk patients,
who may benefit from aggressive intervention with intensive chemotherapy,
While many prognostic markers, including nodal status, hormone-receptor-status, ploidy and
growth fraction and the expression of various oncogenes and proto-oncogenes by the tumor
cells have been proposed as prognostic factors, the results, to date, have been equivocal for
a number of these. Recently there has been much. interest in the prognostic importance of cerbB-
2 protein in breast cancer. Most of these studies have concentrated on
immunohistochemically stainable e-erb-2 in tumor tissue. This dissertation focusses on the
prognostic impact of the soluble c-erbB-2 protein in the serum of breast cancer patients treated
at the Breast Clinic of tne Johannesburg Hospital and University of the Witwatersrand. The
results of this investigation have been reported under the title "Soluble c-erhB-2 fragment in
Serum Correlates With Disease Stage and Predicts for Shortened Survival in Patients with Early
Stage and Advanced Breast Cancer" by H. Kandt, L. Seymour & W.R. Bezwoda, Published
in British Journal of Cancer, Vo170 p739-742" 1994. / Andrew Chakane 2018
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Chromosomal radiosensitivity in South African breast cancer patients before and after radiotherapyMuller, Xanthene 19 March 2013 (has links)
Introduction: Radiosensitivity (RS) of South African women with breast cancer was investigated as it has been studied in European women, but to date this has not been studied in South African women. The micronucleus assay was used to determine the amount of DNA damage on lymphocytes of breast cancer patients.
Materials and Methods: The first component to this study involved the collection of blood samples from breast cancer patients and healthy individuals. For the second component, blood samples from breast cancer patients were collected before and after the completion of radiotherapy (RT). A centromeric micronucleus assay using the Fluorescent in situ Hybridisation (FISH) pancentromeric probe was used to investigate the origin of the micronuclei (MN) and to distinguish between radiation-induced [centromere negative (CM-)] and spontaneous [centromere positive (CM+)] MN.
Results: Micronucleus frequencies were slightly higher in breast cancer patients than those observed in lymphocytes of healthy donors. This was noted for the different radiation doses and indicated a trend towards an enhanced chromosomal radiosensitivity in this cancer population. Results were compared before and after radiotherapy. The micronucleus scores for the 0 Gy (sham irradiated samples) were significantly higher (p < 0.05) post radiotherapy. This is an expected result as ionising radiation causes more damage. However, blood samples from post-therapy patients, were shown to have fewer MN after subsequent in vitro 2 Gy and 4 Gy irradiation respectively. When assessing the centromeric micronucleus assay results, a significantly (p < 0.05) higher number of CM- MN was observed than CM+ MN after RT, thereby indicating that ionising radiation causes more breaks in the chromosomes (clastogenic damage).
Discussion and Conclusion: This study demonstrates that a group of South African breast cancer patients have slightly higher micronucleus frequencies compared to a population of healthy women, indicating a trend towards a higher sensitivity to radiation.
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A comparison between oestrogen and HER-2 immunohistochemical staining of core and excision biopsy specimens in breast cancerVermaak, Jacobus Stephanus 06 February 2014 (has links)
Immunohistochemical staining for oestrogen and human epidermal growth factor receptor
(HER)-2 is essential in the management of breast cancer patients. Two histological
specimens are usually obtained during a breast cancer patient’s treatment: the core biopsy
and the final excision specimen.
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Smoking during first pregnancy and the risk of breast cancer /De Roo, Lisa Anne. January 2004 (has links)
Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 35-43).
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