Global ETD Search

301	A chemical-biology approach for screening novel inhibitors of focal adhesion signaling in relation to breast cancer / Cao, Yangxiezi. January 2008 (has links) Focal adhesion kinase (FAK), a non-receptor kinase, is a key regulator of integrin and focal adhesion signaling required for cancer cell survival, cell migration, and cell invasion. Amplification/Overexpression of FAK occurs in a wide variety of human cancers, supporting a role in carcinogenesis. Moreover, preclinical studies using cancer models where FAK is genetically inhibited indicate that this kinase is a potential therapeutic target to interfere with cancer progression. However, very little progress has been made in the identification of chemical inhibitors for potential therapeutic applications, in contrast to other kinases. Herein, I report optimization of the high-throughput in vitro Glo kinase assay for screening inhibitors of FAK kinase activity. Screening a large library of small molecule chemicals using these assays identified at least twenty FAK inhibitors, including a new FAK inhibitor developed by Pfizer and undergoing human clinical trials, and the non-specific kinase inhibitor staurosporine. Molecular studies of selective FAK inhibitors are undergoing in my host laboratory. In addition to this in vitro assay, I established similar assays to examine FAK kinase and adapter function in intact cells. The latter consists of ErbB-transformed cells deficient in FAK, and their matched cells where wild-type or kinase-dead FAK was restored. Biological characterization of these models revealed that both FAK kinase and adaptor activities cooperate for the regulation of cell migration, cell invasion, and tumor formation. Breast Neoplasms -- drug therapy.
302	Bildterapi vid bröstcancer : kvinnors berättelser i ord och bild / Öster, Inger, January 2007 (has links) Diss. (sammanfattning) Umeå : Univ., 2007. / Härtill 4 uppsatser.
303	Analytical strategies for identifying relevant phenotypes in microarray data / Wennmalm, Kristian, January 2007 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
304	Genetic determinants of postmenopausal breast and endometrial cancer / Kristjana Einarsdóttir, January 2007 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
305	Factors affecting attendance at population-based mammography screening / Lagerlund, Magdalena, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 5 uppsatser.
306	Does cancer originate in utero? : epidemiological evaluation of a hypothesis / Kaijser, Magnus, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 5 uppsatser.
307	Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas / Zhang, Anju, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 5 uppsatser.
308	Genetic susceptibility to breast and endometrial cancer / Wedrén, Sara, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
309	Att som förälder få en cancersjukdom : erfarenheter av föräldraansvar / Elmberger, Eva, January 2004 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.
310	Professional caregivers' experiences of caring for women with breast cancer on a surgical ward / Ödling, Gunvor, January 2004 (has links) Diss. (sammanfattning) Umeå : Univ., 2004. / Härtill 4 uppsatser.

Search results