This thesis investigates the strength behavior of a representative highly skewed and horizontally curved bridge as well as analysis and design procedures for these types of structures. The bridge responses at and above a number of limits in the AASHTO (2007) Specifications are considered. The study includes the evaluation of various attributes of the elastic analysis of the subject bridge. These attributes include: (1) the accuracy of 3-D grid versus 3-D FEA models, (2) first-order versus second-order effects during the construction, (3) the ability to predict layover at bearing lines using simplified equations and (4) the benefit of combining the maximum and concurrent major-axis and flange lateral bending values due to live load compared to combining the maximums due to different live loads when checking the section resistances. The study also addresses the ability of different AASHTO 2007 resistance equations to capture the ultimate strength behavior. This is accomplished by comparing the results from full nonlinear 3-D FEA studies to the elastic design and analysis results. Specifically the use of the 2007 AASHTO moment based one-third rule equations is evaluated for composite sections in positive bending.