Papers, memoirs, diaries, letters and autobiographies from 1791-1807 are studied to determine the relationship between Jefferson and Burr. A limited examination of congressional records for the same period was made. Monographs and biographies of Jefferson, Burr and their contemporaries were studied. This study shows that the relationship between Jefferson and Burr was one of political expediency and that Jefferson's antipathy toward Burr began in 1791 and not as a result of the House presidential election of 1801. The thesis concludes that Jefferson used Burr's political influence in New England to achieve Democratic -Republican control of the federal government and then used the alleged conspiracy between Burr and the Federalists during the House election of 1801 as an excuse to begin Burr's political destruction.