This study presents a conceptual model to investigate the electronic health (E-Health) capability required by healthcare professionals. First, a scale to measure E-Health capability was developed and validated, then it was used to collect the survey data. Second, the partial least squares (PLS) method was used to empirically test the conceptual model and hypotheses through the survey data collected. The empirical results support the proposed structure for E-Health capability encompassing the three skills/knowledge domains: IT governance capability, practice management capability, and business model innovativeness. The findings improve our understanding of the concept of E-Health capability. The conceptual model of E-Health capability is of particular value to those concerned with skills/knowledge training and competency development for healthcare professionals in healthcare organizations. Healthcare organizations can develop E-Health capability profiles for individual healthcare professionals in accordance with their own organization contexts.