Consider a linear regression model with a two-dimensional control vector (x_1, x_2) and an m-dimensional response vector y = (y_1, . . . , y_m). The components of y are correlated with a known covariance matrix. Based on the assumed regression model, there are two problems of interest. The first one is to estimate unknown control vector x_c corresponding to an observed y, where xc will be estimated by the classical estimator. The second one is to obtain a suitable estimation of the control vector x_T corresponding to a given target T = (T_1, . . . , T_m) on the expected responses. Consideration in this work includes the deviation of the expected response E(y_i) from its corresponding target value T_i for each component and defines the optimal control vector x, say x_T , to be the one which minimizes the weighted sum of squares of standardized deviations within the range of x. The objective of this study is to find c-optimal designs for estimating x_c and x_T , which minimize the mean squared error of the estimator of xc and x_T respectively. The comparison of the difference between the optimal calibration design and the optimal design for estimating x_T is provided. The efficiencies of the optimal calibration design relative to the uniform design are also presented, and so are the efficiencies of the optimal design for given target vector relative to the uniform design.

In this dissertation we first consider a parallel linear model with correlated dual responses on a symmetric compact design region and construct locally optimal designs for estimating the location-shift parameter. These locally optimal designs are variant under linear transformation of the design space and depend on the correlation between the dual responses in an interesting and sensitive way. Subsequently, minimax and maximin efficient designs for estimating the location-shift parameter are derived. A comparison of the behavior of efficiencies between the minimax and maximin efficient designs relative to locally optimal designs is also provided. Both minimax or maximin efficient designs have advantage in terms of estimating efficiencies in different situations. Thirdly, we consider a linear regression model with a one-dimensional control variable x and an m-dimensional response variable y=(y_1,...,y_m). The components of y are correlated with a known covariance matrix. The calibration problem discussed here is based on the assumed regression model. It is of interest to obtain a suitable estimation of the corresponding x for a given target T=(T_1,...,T_m) on the expected responses. Due to the fact that there is more than one target value to be achieved in the multiresponse case, the m expected responses may meet their target values at different respective control values. Consideration includes the deviation of the expected response E(y_i) from its corresponding target value T_i for each component and the optimal value of calibration point x, say x_0, is considered to be the one which minimizes the weighted sum of squares of such deviations within the range of x. The objective of this study is to find a locally optimal design for estimating x_0, which minimizes the mean square error of the difference between x_0 and its estimator. It shows the optimality criterion is approximately equivalent to a c-criterion under certain conditions and explicit solutions with dual responses under linear and quadratic polynomial regressions are obtained.