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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
71

Produktion und Oligosaccharidanalyse des klinisch relevanten anti-CD4 monoklonalen Antikorpers MAX16H5 /

Kloth, Claudia. January 1900 (has links)
Thesis--Universitat Leipzig, 2000.
72

The role of Foxp3 in CD4⁺ T cell development and function /

Fontenot, Jason David. January 2003 (has links)
Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 79-94).
73

Characterisation of the immune co-receptor function of CD4

Maekawa, Akiko, Medical Sciences, Faculty of Medicine, UNSW January 2007 (has links)
CD4 is a co-receptor for binding of T cells to antigen-presenting cells (APC) and the primary receptor for human immunodeficiency virus-I. The disulfide bond in the second extracellular domain (D2) of CD4 is reduced on the cell surface, which leads to formation of disulfide-linked homodimers. A large conformational change must take place in D2 to allow for formation of the disulfide-linked dimer. Domain swapping of D2 is the most likely candidate for the conformational change leading to formation of two disulfide-bonds between Cysl30 in one monomer and Cysl59 in the other one (Cys133 and Cysl62 in the mouse CD4). Thus, we hypothesized that the domain swapping of D2 in CD4 regulates its co-receptor function of antigenspecific T cell activation. We found that mild reduction of the extracellular part of human CD4 resulted in formation of disulfide-linked dimers. We then tested the functional significance of dimer formation for co-receptor function using the engineered Jurkat T cell system by expressing wild-type or disulfide-bond mutant mouse CD4. Eliminating the D2 disulfide bond markedly impaired CD4's coreceptor function as assessed by antigen-specific IL-2 production. Exogenous wild type thioredoxin, but not redox-inactive thioredoxin, could inhibit the CD4-mediated IL-2 production, suggesting that the redox state of D2 disulfide bond is controlled by this oxidoreductase. Furthermore, structural modeling of the complex ofthe T cell receptor and domain-swapped CD4 dimer bound to class II major histocompatibility complex and antigen supports the domain-swapped dimer as the immune co-receptor. The known involvement of D4 residues Lys318 and Gln344 in dimer formation isalso accommodated by this model. These findings imply that disulfide-linked dimeric CD4 is the preferred functional co-receptor for binding to APC. Strategies to promote dimerisation of CD4 should, therefore, enhance the immune response, while inhibiting dimer formation is predicted to be immunosuppressive.
74

Generierung regulatorischer T-Zellen aus naiven CD4+-CD45RA+-T-Zellen durch Anti-CD4-Interaktion

Mischke, Dirk January 2007 (has links)
Zugl.: Leipzig, Univ., Diss., 2007
75

CD28null T cells in rheumatoid arthritis and inflammatory myopathies : cellular characterization and clinical relevance /

Fasth, Andreas, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
76

Targeting Th2 transcription factors in experimental asthma

Kinyanjui, Margaret. January 1900 (has links)
Thesis (Ph.D.). / Written for the Dept. of Medicine. Title from title page of PDF (viewed 2008/05/09). Includes bibliographical references.
77

Molecular events in human T cell activation : CD4, CD8 and the human Lyt-3 molecules /

DiSanto, James Philip. January 1989 (has links)
Thesis (Ph. D.)--Cornell University, 1989. / Vita. Includes bibliographical references.
78

The role of CD4 T cell help during the CD8 T cell response /

Sun, Joseph C. January 2005 (has links)
Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 96-103).
79

The modulation of CD4⁺ T lymphocyte activity by adenosine A₂[A] receptor activation /

Lappas, Courtney Marcia. January 2006 (has links)
Thesis (Ph. D.)--University of Virginia, 2006. / Includes bibliographical references. Also available online through Digital Dissertations.
80

Modulation of naive CD4+ Tcell activation and dendritic cell function in the lungs during pulmonary mycobacterial infection

Anis, Mursalin M. January 2007 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2007. / [School of Medicine] Department of Pathology. Includes bibliographical references. Available online via OhioLINK's ETD Center.

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