Expectancies about the effects of alcohol predict alcohol consumption among adolescent children. Although alcohol-expectancy measures have been validated to use with English speaking populations, there is currently no available information on the psychometric properties of the Comprehensive Effects of Alcohol (CEOA) questionnaire with Spanish speaking populations. Using confirmatory factor analysis (CFA), the factor structure of the Spanish version of the CEOA was assessed in a set of scores obtained from a sample of adolescents from Mexico (N = 345). The results replicated the 7-factor structure of the CEOA. Moreover, CEOA factor-scale derived scores predicted alcohol use. Overall, the CEOA-Spanish appears to be a valid measure of alcohol expectancies for use with Mexican adolescents.