Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1997. / Added t.p. with thesis statement inserted.

Ciprofloxacin is a widely prescribed antibiotic which causes idiopathic sensory adverse effects and is known to induce oxidative stress. Dopaminergic cells are known to have intrinsic sensitivity to oxidative stress. To investigate whether ciprofloxacin potentiates cy- totoxicity of dopamine, effects of combined drug treatments on cell viability were assessed by resazurin reduction, and effects on mitochondrial health were assessed by morphology. The cell viability assays suggest that ciprofloxacin significantly potentiates dopamine cytotoxicity at clinically relevant doses, although dopamine possibly interferes with the viability assay. Effects of drug treatments on mitochondrial morphology were inconclusive.

No description available.

The f)-lactam or azetidinone 4-membered heterocyclic nng system has been synthesised by many different synthetic strategies and these are well documented in the literature. Many of these strategies give substituted azetidinone rings displaying defined stereochemistry which are used as the building block for many modern day antibiotics. It was therefore intended to pursue a method of azetidinone ring formation using cheap and readily available starting materials employing a [2+2] cycloaddition reaction which, according to the literature, had only a few examples and was seen to be an area ripe for research. Taking urethane in anhydrous THF and metalating with n-butyl lithium, followed by the subsequent addition of phenyl vinyl sulfone, it was envisaged that the two would react in such a way to give the -l-membered azetidinone ring. It was found however that the carbon-nitrogen bond was formed but subsequent cyclisation did not follow and therefore no azetidinone was formed. Although azetidinone ring was not detected the novel compound N,N-bis-(phenylsulfonylethyl) urethane was isolated. This compound was of interest since it was hoped that it could provide a new route to substituted pyridines. Various methods were undertaken in an attempt to cyclise this molecule via the generation of a-sulfonyl carbanions and reactions with a variety of electrophiles. During our experiments no cyclised products were detected. TIle replacement of phenyl sulfonyl group with triphenylphosphonium bromide provided a new hope for azetidinone synthesis since its ability to stabilise a-sulfonyl carbanions and promote reaction with electrophiles was well established. Experiments of this nature failed to produce an azetidinone. TIle next stage of research was to investigate a new route to the production of quinolone antibiotics. Quinolones, particularly those which are furnished with a fluorine at C-6 position, are the new generation of antibiotics which exhibit a high activity and selectivity towards pathogens which have become resistant to older antibiotics such as penicillin. Needless to say their importance in the pharmaceutical industry has increased dramatically over recent years and research into the improvement of synthetic strategies towards the total synthesis of these molecules has attracted much commercial interest. Meth-Cohn showed that quinolones can be formed in excellent yield by the reaction of N-alkylformanilides in phosphorus oxychloride and activated acid chlorides e.g. methyl malonyl chloride. This approach is examined regarding the synthesis of both novel and known quinolone antibiotics (norfloxacin and ciprofloxacin). Work on this topic has produced encouraging results with the synthesis of important antibacterial intermediates.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

No / Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.

Class of 2012 Abstract / Specific Aims: Determine the incidence of scheduled co-administration times in handwritten (paper) and electronic prepared medication administration records of oral ciprofloxacin and oral moxifloxacin with interacting substances that can affect fluoroquinolone gastrointestinal absorption. Also, determine the incidence of actual co-administration of oral ciprofloxacin and moxifloxacin with interacting substances that can affect fluoroquinolone gastrointestinal absorption with electronic and handwritten prepared medication administration records. Methods: Retrospective data was obtained by a chart review of patients from an academic medical center for a one month period before (May 2010) and after (August 2010) implementation of an electronic prepared medical administration record system. The scheduled time and actual time given for all fluoroquinolone antibiotics, as well as all possible interacting substances, were recorded. Main Results: A total of 99 subjects were included in this study (36 paper and 63 electronic). There was no statistical difference (p=0.47) between the percentage of scheduling errors for the electronic prepared medication administration records, 25.3%, compared to the paper medication administration records, 22.1%. However, there was a decrease in the percentage of actual co-administrations of fluoroquinolones with interacting substances for the electronic prepared MARs compared to paper prepared medication administration records; 22.3% and 32.1% respectfully (p=0.03). Conclusions: After implementing electronic prepared medication administration records at an academic institution, co-administration errors went down even though the amount of scheduling errors did not decrease.

Zugl.: Berlin, Freie Univ., Diss., 2006