Two pyrrolo[2,3-d]pyrimidines and a nucleoside analogue have been prepared. The nucleobases were obtained by spontaneous cyclisation of 4-aminopyrimidyl-acetaldehydes as an acetal. The adenosine analogue has been made by glycosylation of a suitable sugar derivative with the corresponding heterocyclic base. This nucleoside can be converted into fluorescently-labeled chain-terminating substrates for DNA polymerase after subsequent triphosphorylation and coupling to through-bond energy transfer systems. Fluorescein-based donor components to be incorporated into through-bond energy transfer systems have been prepared. The synthesis of 5-ethynylfluorescein-(5-tert-butoxycarbonyl)-pentyl ester has been executed in five steps from 1,3-dihydroxybenzene and phthalic anhydride. The donor fluorescein carboxylate has been alkylated with the tert-butyl ester of 6-bromohexanoic acid to provide a handle for attachment to biomolecules. In the context of regioisomerically pure halofluoresceins, besides the synthesis of pure regioisomers of bromofluorescein derivatives, 5-iodosulfofluorescein and pure regioisomers of 5-nitrofluorescein diacetate, as an intermediate in the synthesis of 5-iodofluoresceins, have been synthesized. New rhodamine-based acceptor components with extended aromatic systems have been prepared from an affordable starting material, tetralin. The attempts to isolate them via repeated recrystallizations and flash chromatography have been unsuccessful. However, these pyrylium cations are expected to fluoresce at longer wavelengths.

Automotive industry in China is probably one of the most potential emerging markets all over the world along with the trend of the ¡§China Flu¡¨. More than that, the well-know market demand over the 2002 is prosperously exceeded over the average estimation. The total vehicle production quantity is 3.25 million pieces versus almost the equivalent sold out quantity, the attractive numbers pushing China Auto market upward the rank of the 4th largest regional market, and become the only market cranking upward with the growth rate at 30%, while most of the other markets are suffering severely worldwide recession. China automakers and automotive electronic components makers become world-class auto manufacturers' strategic partners. Therefore, the research deals with the extent to which multinational tier 1 and tier 2 enterprises and China local makers clustering segment as the new China auto industrial landscape rely on Taiwanese automotive components suppliers with the most suitable entry mode as well as the competing advantage throughout the newly emerging supply chain in China OE segments, how Taiwanese suppliers find a way to be upgraded as a global player via the collaboration synergy of China market. The methodology for the research is utilized the case study approach and the interview with the leading edge industrial players for both China auto makers and multinational Tier 1 giants. After literature review and case study analysis, we highlight the most suitable entry strategy as ¡§niche strategy¡¨ and ¡§collaboration alliance¡¨ with the deliberation in terms of the Taiwanese makers SWOT analysis. For Taiwanese makers, they have some advantages, such as 1). leverage of resources; 2).integrator role played between Western and China connection; 3).booster of Taiwan¡¦s globalization; 4).enlarging the market place from regional to international level; 5).smooth over the political conflict for enhanced collaboration to reach the win-win synergic solution. Tenth Five-Year Plan published in June 2001 as the highest regulatory that is the major forces driving China automotive industry forward, in which the motor vehicle production was expected to reach some 3.2 million in 2005, including 1.1 million cars. Automotive industrial added value will reach RMB 130 billion, accounting for 1% of GDP. By 2005, the 2-3 large automotive enterprise groups ( First Auto Works, Shanghai Auto Industry Corp.,and Dongfeng Motor Corp.) with certain international competitiveness will be formed and fully supported by the state, making use of all kinds of preferential policies, whose products share over 70% of domestic market with some exports. The 5-10 large enterprise groups for automotive parts and components with initial international competitiveness will be built up. The top three enterprise groups for key automotive parts and components will have market share 70% of domestic market. Technical renovation projects in line with the Tenth Five-Year Plan of automotive industry and beneficial to the restructuring of automotive industry will be given priority to indirect financing and a modern development, production and marketing system will be encouraged to establish. Consequently, the State encourages the autonomous development of leading parts and components enterprises to enhance their competitiveness. Different ownerships are encouraged to participate in the development of auto part and component industry with the policy of the strategic alliance in order to innovate a newly modern value chain with the world wide expertise ¡¨clustering effects¡¨. Leading enterprises emerging as ¡§super suppliers¡¨ as innovation term of ¡§tier 0.5¡¨ for Automotive parts and components supported by 3 OE Giants FAW, SAIC and DMC. The tier 0.5 super suppliers such as Fawer under FAW, STEC under SAIC and DFT under DMC will be guided to develop the specialization of the system provider and module integrator for effectiveness of economies of scale. The research has two implications ---the interface strategy of Taiwan automakers is the ¡§niche strategy¡¨ and ¡§collaboration alliance¡¨. As far as the penetration and competing strategy development of Chinese market is concerned, the ¡§niche strategy strategic role played by Taiwanese have an absolute effect on the second level OE car makers to avoid competing with larger firms by targeting small markets of little or no interesting to the larger firms. Collaboration alliance connecting both of Mainland China domestic makers to the western countries facilitated by horizontal collaboration for market development and technology enhancement, because Taiwan belongs to the same cultural region as Mainland China. Besides. The research also suggests the competing strategies; such as reinforce the self-technology capability incubator, leverage of Taiwan IT and IC industry competing advantage to back up the automotive electronic upgrade, emphasize the role played as an multinational enterprise, strengthen the global wise alliance as well as the worldwide marketing channel connection. The active participation of Taiwanese suppliers is also an essential factor that raises the status as interface strategy. Taiwan makes use of core competences to play the role of ¡§critical unique link¡¨ without being left out from the emerging value chain of the highly potential China market.

Two pyrrolo[2,3-d]pyrimidines and a nucleoside analogue have been prepared. The nucleobases were obtained by spontaneous cyclisation of 4-aminopyrimidyl-acetaldehydes as an acetal. The adenosine analogue has been made by glycosylation of a suitable sugar derivative with the corresponding heterocyclic base. This nucleoside can be converted into fluorescently-labeled chain-terminating substrates for DNA polymerase after subsequent triphosphorylation and coupling to through-bond energy transfer systems. Fluorescein-based donor components to be incorporated into through-bond energy transfer systems have been prepared. The synthesis of 5-ethynylfluorescein-(5-tert-butoxycarbonyl)-pentyl ester has been executed in five steps from 1,3-dihydroxybenzene and phthalic anhydride. The donor fluorescein carboxylate has been alkylated with the tert-butyl ester of 6-bromohexanoic acid to provide a handle for attachment to biomolecules. In the context of regioisomerically pure halofluoresceins, besides the synthesis of pure regioisomers of bromofluorescein derivatives, 5-iodosulfofluorescein and pure regioisomers of 5-nitrofluorescein diacetate, as an intermediate in the synthesis of 5-iodofluoresceins, have been synthesized. New rhodamine-based acceptor components with extended aromatic systems have been prepared from an affordable starting material, tetralin. The attempts to isolate them via repeated recrystallizations and flash chromatography have been unsuccessful. However, these pyrylium cations are expected to fluoresce at longer wavelengths.

Thesis (M. Phil.)--University of Hong Kong, 1988.

The re-usability and modularity of components reduce the cost and complexity of the software design. It is difficult to predict run-time scenarios covering all possible circumstances to ensure that the components are full compatible with the system. Monitoring run-time behaviours of components presents a close view of the component qualities. The existing monitoring approaches either implement applications with built-in monitoring features, or observe the external resource and events to predict the status of the components. In this thesis work, we propose an approach to monitor the run-time behaviours of components with aspect-oriented wrappers and contracts. We design monitoring wrappers to encapsulate the monitored components. The wrapper has the access to interfaces and properties of the wrapped component. We adopt the methodology of Design by Contract to enforce security policies on component wrappers. The contracts define the mutual obligations of two interacting components. The policies implemented in contracts are woven into component wrappers as separate aspect modules. If the component contains any flaws, the wrappers can monitor the behaviours and prevent failures propagating into the wrapped components and the rest of the system. This approach assures that the system is running in a safe environment with the erroneous behaviours or failures detected appropriately. Secure access between the wrappers guarantees a secure environment for the wrapped components. We conducted experiments on the run-time monitoring of SQL Injection and Cross Site Scripting attacks. We designed cross-cutting concerns such as logging for components to illustrate monitoring components without touching the underlying components. Monitoring on access control is also possible and feasible to add as an additional concern and is also demonstrated in the experiments. The results show that the framework is very flexible to impose separate policies as aspects on component wrappers without the modifications of the underlying components. / Thesis (Master, Computing) -- Queen's University, 2011-01-02 20:43:16.884

No description available.

No description available.

No description available.

Thesis (M.S.)--Rochester Institute of Technology, 1984. / Typescript. Includes bibliographical references (leaf 30).

Thesis (M.S.)--Oregon State University, 2004. / Printout. Includes bibliographical references (leaves 61-62). Also available on the World Wide Web.